{"doi":"10.1016/j.celrep.2024.114347","title":"Hair follicles modulate skin barrier function","abstract":"Our skin provides a protective barrier that shields us from our environment. Barrier function is typically associated with the interfollicular epidermis; however, whether hair follicles influence this process remains unclear. Here, we utilize a potent genetic tool to probe barrier function by conditionally ablating a quintessential epidermal barrier gene, Abca12, which is mutated in the most severe skin barrier disease, harlequin ichthyosis. With this tool, we deduced 4 ways by which hair follicles modulate skin barrier function. First, the upper hair follicle (uHF) forms a functioning barrier. Second, barrier disruption in the uHF elicits non-cell-autonomous responses in the epidermis. Third, deleting Abca12 in the uHF impairs desquamation and blocks sebum release. Finally, barrier perturbation causes uHF cells to move into the epidermis. Neutralizing IL-17a, whose expression is enriched in the uHF, partially alleviated some disease phenotypes. Altogether, our findings implicate hair follicles as multi-faceted regulators of skin barrier function.","journal":"Cell Reports","year":2024,"id":427391,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9601,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1227562,"name":"Rachel E Benedeck","orcid":"0000-0001-9580-3882","position":1,"is_corresponding":false},{"id":1142749,"name":"Matthew T. Mattoon","orcid":null,"position":2,"is_corresponding":false},{"id":898899,"name":"Jamie K. Peterson","orcid":"0000-0002-5495-8578","position":3,"is_corresponding":false},{"id":1227563,"name":"Arlee L. Mesler","orcid":"0000-0003-3510-4929","position":4,"is_corresponding":false},{"id":898900,"name":"Natalia A. Veniaminova","orcid":"0000-0003-1174-4403","position":5,"is_corresponding":false},{"id":1228093,"name":"Danielle J. Gardon","orcid":null,"position":6,"is_corresponding":false},{"id":899339,"name":"Shih-Ying Tsai","orcid":null,"position":7,"is_corresponding":false},{"id":527281,"name":"Yoshikazu Uchida","orcid":"0000-0002-4980-3416","position":8,"is_corresponding":false},{"id":847818,"name":"Sunny Y. Wong","orcid":"0000-0002-0222-2681","position":9,"is_corresponding":false},{"id":899341,"name":"Noah C. Ford","orcid":null,"position":0,"is_corresponding":true}],"reference_count":93,"raw_metadata":null,"created_at":"2026-07-19T01:58:47.805440Z","pmid":"38941190","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}