{"doi":"10.1016/j.celrep.2024.114346","title":"Impaired islet function and normal exocrine enzyme secretion occur with low inter-regional variation in type 1 diabetes","abstract":"Histopathological heterogeneity in the human pancreas is well documented; however, functional evidence at the tissue level is scarce. Herein, we investigate in situ glucose-stimulated islet and carbachol-stimulated acinar cell secretion across the pancreas head (PH), body (PB), and tail (PT) regions in donors without diabetes (ND; n = 15), positive for one islet autoantibody (1AAb+; n = 7), and with type 1 diabetes (T1D; <14 months duration, n = 5). Insulin, glucagon, pancreatic amylase, lipase, and trypsinogen secretion along with 3D tissue morphometrical features are comparable across regions in ND. In T1D, insulin secretion and beta-cell volume are significantly reduced within all regions, while glucagon and enzymes are unaltered. Beta-cell volume is lower despite normal insulin secretion in 1AAb+, resulting in increased volume-adjusted insulin secretion versus ND. Islet and acinar cell secretion in 1AAb+ are consistent across the PH, PB, and PT. This study supports low inter-regional variation in pancreas slice function and, potentially, increased metabolic demand in 1AAb+.","journal":"Cell Reports","year":2024,"id":425092,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9644,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1223224,"name":"Ana Karen Mojica-Avila","orcid":null,"position":1,"is_corresponding":false},{"id":1223225,"name":"Drew T. Bloss","orcid":null,"position":2,"is_corresponding":false},{"id":293549,"name":"Christian M. Cohrs","orcid":null,"position":3,"is_corresponding":false},{"id":1222675,"name":"Cameron T. Manson","orcid":"0009-0003-5371-6483","position":4,"is_corresponding":false},{"id":251267,"name":"Amanda L. Posgai","orcid":"0000-0002-9491-0958","position":5,"is_corresponding":false},{"id":707815,"name":"MacKenzie D. Williams","orcid":"0000-0003-3473-2747","position":6,"is_corresponding":false},{"id":356517,"name":"Maigan A. Brusko","orcid":"0000-0002-4331-2202","position":7,"is_corresponding":false},{"id":291776,"name":"Edward A. Phelps","orcid":"0000-0001-8666-805X","position":8,"is_corresponding":false},{"id":477240,"name":"Clive Wasserfall","orcid":"0000-0002-3522-8932","position":9,"is_corresponding":false},{"id":291777,"name":"Stephan Speier","orcid":"0000-0002-4561-7085","position":10,"is_corresponding":false},{"id":23929,"name":"Mark A. Atkinson","orcid":"0000-0001-8489-4782","position":11,"is_corresponding":false},{"id":293550,"name":"Denise M. Drotar","orcid":null,"position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:58:26.927596Z","pmid":"38850534","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}