{"doi":"10.1016/j.celrep.2024.114240","title":"linc-ADAIN, a human adipose lincRNA, regulates adipogenesis by modulating KLF5 and IL-8 mRNA stability","abstract":"Adipose tissue remodeling and dysfunction, characterized by elevated inflammation and insulin resistance, play a central role in obesity-related development of type 2 diabetes (T2D) and cardiovascular diseases. Long intergenic non-coding RNAs (lincRNAs) are important regulators of cellular functions. Here, we describe the functions of linc-ADAIN (adipose anti-inflammatory), an adipose lincRNA that is downregulated in white adipose tissue of obese humans. We demonstrate that linc-ADAIN knockdown (KD) increases KLF5 and interleukin-8 (IL-8) mRNA stability and translation by interacting with IGF2BP2. Upregulation of KLF5 and IL-8, via linc-ADAIN KD, leads to an enhanced adipogenic program and adipose tissue inflammation, mirroring the obese state, in vitro and in vivo. KD of linc-ADAIN in human adipose stromal cell (ASC) hTERT adipocytes implanted into mice increases adipocyte size and macrophage infiltration compared to implanted control adipocytes, mimicking hallmark features of obesity-induced adipose tissue remodeling. linc-ADAIN is an anti-inflammatory lincRNA that limits adipose tissue expansion and lipid storage.","journal":"Cell Reports","year":2024,"id":444660,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9513,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":328705,"name":"Sebastian Ho","orcid":"0000-0002-5947-9728","position":1,"is_corresponding":false},{"id":314678,"name":"Johana Coronel","orcid":"0000-0002-9257-0849","position":2,"is_corresponding":false},{"id":1260575,"name":"Lucie Zhu","orcid":null,"position":3,"is_corresponding":false},{"id":618342,"name":"Wen Liu","orcid":"0000-0001-6565-4812","position":4,"is_corresponding":false},{"id":225050,"name":"Chenyi Xue","orcid":"0000-0002-8829-7659","position":5,"is_corresponding":false},{"id":1201425,"name":"Eunyoung Kim","orcid":"0000-0002-9749-9930","position":6,"is_corresponding":false},{"id":905319,"name":"Esther Cynn","orcid":null,"position":7,"is_corresponding":false},{"id":1260126,"name":"Caio V. Matias","orcid":"0000-0001-8321-5581","position":8,"is_corresponding":false},{"id":107945,"name":"Rajesh K. Soni","orcid":"0000-0002-4556-4358","position":9,"is_corresponding":false},{"id":103956,"name":"Chen Wang","orcid":"0000-0001-7857-5435","position":10,"is_corresponding":false},{"id":104430,"name":"Iuliana Ionita‐Laza","orcid":"0000-0002-9001-2026","position":11,"is_corresponding":false},{"id":707634,"name":"Robert C. Bauer","orcid":"0000-0001-9752-9645","position":12,"is_corresponding":false},{"id":707891,"name":"Leila S. Ross","orcid":"0000-0003-4360-5213","position":13,"is_corresponding":false},{"id":656474,"name":"Yiying Zhang","orcid":"0000-0001-8197-7558","position":14,"is_corresponding":false},{"id":640711,"name":"Silvia Corvera","orcid":"0000-0002-0009-4129","position":15,"is_corresponding":false},{"id":299217,"name":"Susan K. Fried","orcid":"0000-0003-1101-9332","position":16,"is_corresponding":false},{"id":75509,"name":"Muredach P. Reilly","orcid":"0000-0002-3035-9386","position":17,"is_corresponding":false},{"id":904787,"name":"M. O'Reilly","orcid":"0000-0001-6346-1881","position":0,"is_corresponding":true}],"reference_count":94,"raw_metadata":null,"created_at":"2026-07-19T02:01:37.886033Z","pmid":"38753486","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}