{"doi":"10.1016/j.celrep.2024.114206","title":"IL-22 promotes mucin-type O-glycosylation and MATH1+ cell-mediated amelioration of intestinal inflammation","abstract":"The interleukin (IL)-22 cytokine can be protective or inflammatory in the intestine. It is unclear if IL-22 receptor (IL-22Ra1)-mediated protection involves a specific type of intestinal epithelial cell (IEC). By using a range of IEC type-specific Il22Ra1 conditional knockout mice and a dextran sulfate sodium (DSS) colitis model, we demonstrate that IL-22Ra1 signaling in MATH1 + cells (goblet and progenitor cells) is essential for maintaining the mucosal barrier and intestinal tissue regeneration. The IL-22Ra1 signaling in IECs promotes mucin core-2 O-glycan extension and induces beta-1,3-galactosyltransferase 5 (B3GALT5) expression in the colon. Adenovirus-mediated expression of B3galt5 is sufficient to rescue Il22Ra1 IEC mice from DSS colitis. Additionally, we observe a reduction in the expression of B3GALT5 and the Tn antigen, which indicates defective mucin O-glycan, in the colon tissue of patients with ulcerative colitis. Lastly, IL-22Ra1 signaling in MATH1 + progenitor cells promotes organoid regeneration after DSS injury. Our findings suggest that IL-22-dependent protective responses involve O-glycan modification, proliferation, and differentiation in MATH1 + progenitor cells.","journal":"Cell Reports","year":2024,"id":425052,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1223193,"name":"Michael Beaupre","orcid":null,"position":1,"is_corresponding":false},{"id":1223194,"name":"Cecilia Villegas-Novoa","orcid":null,"position":2,"is_corresponding":false},{"id":1213129,"name":"Kiyoshi Shiomitsu","orcid":"0009-0000-6427-1721","position":3,"is_corresponding":false},{"id":1213910,"name":"Stephen Gaudino","orcid":null,"position":4,"is_corresponding":false},{"id":1223195,"name":"Suzanne Tawch","orcid":null,"position":5,"is_corresponding":false},{"id":1223196,"name":"Ruhee Damle","orcid":null,"position":6,"is_corresponding":false},{"id":980925,"name":"Cody Kempen","orcid":null,"position":7,"is_corresponding":false},{"id":279898,"name":"Biswa Choudhury","orcid":null,"position":8,"is_corresponding":false},{"id":64947,"name":"Jeremy P. McAleer","orcid":null,"position":9,"is_corresponding":false},{"id":367074,"name":"Brian S. Sheridan","orcid":"0000-0002-3299-5888","position":10,"is_corresponding":false},{"id":1222629,"name":"Paula Denoya","orcid":"0000-0001-8437-7793","position":11,"is_corresponding":false},{"id":262528,"name":"Richard S. Blumberg","orcid":"0000-0002-9704-248X","position":12,"is_corresponding":false},{"id":929542,"name":"Patrick Hearing","orcid":"0000-0003-0400-1660","position":13,"is_corresponding":false},{"id":284766,"name":"Nancy L. Allbritton","orcid":"0000-0002-9242-768X","position":14,"is_corresponding":false},{"id":64938,"name":"Pawan Kumar","orcid":"0000-0003-3628-452X","position":15,"is_corresponding":false},{"id":1213127,"name":"Ankita Singh","orcid":"0000-0003-0738-6914","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:26.927596Z","pmid":"38733584","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}