{"doi":"10.1016/j.celrep.2024.114142","title":"Itaconate alleviates diet-induced obesity via activation of brown adipocyte thermogenesis","abstract":null,"journal":"Cell Reports","year":2024,"id":620485,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1601815,"name":"Xianju Li","orcid":"0000-0003-1778-7164","position":1,"is_corresponding":false},{"id":1601816,"name":"Yanni Quan","orcid":null,"position":2,"is_corresponding":false},{"id":568474,"name":"Jiawen Chen","orcid":"0000-0001-7571-2860","position":3,"is_corresponding":false},{"id":995535,"name":"Jiarui Liu","orcid":"0000-0002-1828-158X","position":4,"is_corresponding":false},{"id":1601817,"name":"Nairen Zheng","orcid":null,"position":5,"is_corresponding":false},{"id":593434,"name":"Shuwen Liu","orcid":"0000-0001-6346-5006","position":6,"is_corresponding":false},{"id":1583278,"name":"Yini Wang","orcid":null,"position":7,"is_corresponding":false},{"id":1062588,"name":"Wanlin Liu","orcid":"0000-0001-6944-0547","position":8,"is_corresponding":false},{"id":1474845,"name":"Chen Qiu","orcid":"0000-0003-0825-450X","position":9,"is_corresponding":false},{"id":710398,"name":"Yi Wang","orcid":"0000-0001-8043-4869","position":10,"is_corresponding":false},{"id":640179,"name":"Ruimao Zheng","orcid":"0000-0001-7404-2607","position":11,"is_corresponding":false},{"id":325912,"name":"Jun Qin","orcid":"0000-0002-2647-9270","position":12,"is_corresponding":false},{"id":1139032,"name":"Zihan Yu","orcid":"0000-0001-8439-7583","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Itaconate alleviates diet-induced obesity via activation of brown adipocyte thermogenesis","abstract":"Despite medical advances, there remains an unmet need for better treatment of obesity. Itaconate, a product of the decarboxylation of the tricarboxylic acid cycle intermediate cis-aconitate, plays a regulatory role in both metabolism and immunity. Here, we show that itaconate, as an endogenous compound, counteracts high-fat-diet (HFD)-induced obesity through leptin-independent mechanisms in three mouse models. Specifically, itaconate reduces weight gain, reverses hyperlipidemia, and improves glucose tolerance in HFD-fed mice. Additionally, itaconate enhances energy expenditure and the thermogenic capacity of brown adipose tissue (BAT). Unbiased proteomic analysis reveals that itaconate upregulates key proteins involved in fatty acid oxidation and represses the expression of lipogenic genes. Itaconate may provoke a major metabolic reprogramming by inducing fatty acid oxidation and suppression of fatty acid synthesis in BAT. These findings highlight itaconate as a potential activator of BAT-mediated thermogenesis and a promising candidate for anti-obesity therapy.","is_dataset_classified":null,"base_score":3.332204510175204,"endowment":3.332204510175204,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38691458","pmcid":null,"openalex_id":"https://openalex.org/W4396516679","authors":[],"funders":[{"funder_name":"National Key Research and Development Program of China","grant_id":"2022YFA1303200","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32088101","title":null}],"total_grants":2,"fwci":6.4926,"citation_percentile":0.9755109,"influential_citations":0,"citation_trend":[{"year":2024,"count":2},{"year":2025,"count":15},{"year":2026,"count":10}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.cell.com/article/S2211124724004704/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2211124724004704/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124724004704?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124724004704?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2024.114142","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38691458","host_type":"repository"},{"url":"https://doaj.org/article/10d0695edfb7427db75c5b62238f62db","host_type":"repository"}],"fields_of_study":["Adipose Tissue and Metabolism","Cancer, Hypoxia, and Metabolism","Diet and metabolism studies"],"mesh_terms":["Animals","Adipose Tissue, Brown","Energy Metabolism","Male","Mice, Inbred C57BL","Obesity","Succinates","Thermogenesis","Mice","Adipocytes, Brown","Diet, High-Fat"],"keywords":["Thermogenesis","Beta oxidation","Brown adipose tissue","Fatty acid synthesis","Lipogenesis","Fatty acid","Biology","Leptin","Citric acid cycle","Internal medicine","Endocrinology","Activator (genetics)","AMPK","Decarboxylation","Metabolism","Biochemistry","Adipose tissue","Obesity","Medicine","Gene","Enzyme","Protein kinase A","Proteomics","Brown Adipocyte","Itaconate","Cp: Metabolism"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Affordable and clean energy"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T11:13:42.232866Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}