{"doi":"10.1016/j.celrep.2024.114140","title":"Sex-specific expression of distinct serotonin receptors mediates stress vulnerability of adult hippocampal neural stem cells in mice","abstract":"Women are more vulnerable to stress and have a higher likelihood of developing mood disorders. The serotonin (5HT) system has been highly implicated in stress response and mood regulation. However, sex-dependent mechanisms underlying serotonergic regulation of stress vulnerability remain poorly understood. Here, we report that adult hippocampal neural stem cells (NSCs) of the Ascl1 lineage (Ascl1-NSCs) in female mice express functional 5HT1A receptors (5HT1ARs), and selective deletion of 5HT1ARs in Ascl1-NSCs decreases the Ascl1-NSC pool only in females. Mechanistically, 5HT1AR deletion in Ascl1-NSCs of females leads to 5HT-induced depolarization mediated by upregulation of 5HT7Rs. Furthermore, repeated restraint stress (RRS) impairs Ascl1-NSC maintenance through a 5HT1AR-mediated mechanism. By contrast, Ascl1-NSCs in males express 5HT7R receptors (5HT7Rs) that are downregulated by RRS, thus maintaining the Ascl1-NSC pool. These findings suggest that sex-specific expression of distinct 5HTRs and their differential interactions with stress may underlie sex differences in stress vulnerability.","journal":"Cell Reports","year":2024,"id":429347,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9456,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":290963,"name":"Hechen Bao","orcid":"0000-0002-2768-0611","position":1,"is_corresponding":false},{"id":546745,"name":"Andrew Crowther","orcid":"0000-0001-9269-6188","position":2,"is_corresponding":false},{"id":290962,"name":"Yadong Li","orcid":"0000-0002-5977-8760","position":3,"is_corresponding":false},{"id":1070697,"name":"Ze-Ka Chen","orcid":"0000-0002-1629-9882","position":4,"is_corresponding":false},{"id":497254,"name":"Dalton S. Tart","orcid":"0000-0002-8718-349X","position":5,"is_corresponding":false},{"id":307985,"name":"Brent Asrican","orcid":"0000-0003-3434-9852","position":6,"is_corresponding":false},{"id":1231446,"name":"Libo Zhang","orcid":"0000-0002-8601-7705","position":7,"is_corresponding":false},{"id":135505,"name":"Juan Song","orcid":"0000-0002-7836-343X","position":8,"is_corresponding":false},{"id":290964,"name":"Yan‐Jia Luo","orcid":"0000-0002-1288-438X","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T01:59:06.668462Z","pmid":"38656873","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}