{"doi":"10.1016/j.celrep.2024.113927","title":"ALK upregulates POSTN and WNT signaling to drive neuroblastoma","abstract":"Neuroblastoma is the most common extracranial solid tumor of childhood. While MYCN and mutant anaplastic lymphoma kinase ( ALK F1174L ) cooperate in tumorigenesis, how ALK contributes to tumor formation remains unclear. Here, we used a human stem cell-based model of neuroblastoma. Mis-expression of ALK F1174L and MYCN resulted in shorter latency compared to MYCN alone. MYCN tumors resembled adrenergic, while ALK/MYCN tumors resembled mesenchymal, neuroblastoma. Transcriptomic analysis revealed enrichment in focal adhesion signaling, particularly the extracellular matrix genes POSTN and FN1 in ALK/MYCN tumors. Patients with ALK -mutant tumors similarly demonstrated elevated levels of POSTN and FN1 . Knockdown of POSTN , but not FN1 , delayed adhesion and suppressed proliferation of ALK/MYCN tumors. Furthermore, loss of POSTN reduced ALK-dependent activation of WNT signaling. Reciprocally, inhibition of the WNT pathway reduced expression of POSTN and growth of ALK/MYCN tumor cells. Thus, ALK drives neuroblastoma in part through a feedforward loop between POSTN and WNT signaling.","journal":"Cell Reports","year":2024,"id":426841,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":625855,"name":"Wanqi Fang","orcid":"0000-0002-8791-7262","position":1,"is_corresponding":false},{"id":289102,"name":"Alvin Farrel","orcid":"0000-0003-1087-9840","position":2,"is_corresponding":false},{"id":1226338,"name":"Linwei Li","orcid":"0000-0003-2372-6536","position":3,"is_corresponding":false},{"id":1226339,"name":"Antonios Chronopoulos","orcid":"0000-0001-8752-5026","position":4,"is_corresponding":false},{"id":634192,"name":"Nicole Nasholm","orcid":"0000-0002-5451-4985","position":5,"is_corresponding":false},{"id":1138489,"name":"Bo Cheng","orcid":"0000-0002-1236-8262","position":6,"is_corresponding":false},{"id":238687,"name":"Tina Zheng","orcid":null,"position":7,"is_corresponding":false},{"id":969264,"name":"Hiroyuki Yoda","orcid":"0000-0002-5528-8940","position":8,"is_corresponding":false},{"id":1226851,"name":"Megumi J. Barata","orcid":null,"position":9,"is_corresponding":false},{"id":1226852,"name":"Tania B. Porras","orcid":null,"position":10,"is_corresponding":false},{"id":1226340,"name":"Matthew L. Miller","orcid":"0000-0003-0416-016X","position":11,"is_corresponding":false},{"id":1226853,"name":"Qiqi Zhen","orcid":null,"position":12,"is_corresponding":false},{"id":1226854,"name":"Lisa Ghiglieri","orcid":null,"position":13,"is_corresponding":false},{"id":634191,"name":"Lauren McHenry","orcid":"0000-0001-9629-5605","position":14,"is_corresponding":false},{"id":1167571,"name":"Linyu Wang","orcid":"0000-0002-5455-3503","position":15,"is_corresponding":false},{"id":440340,"name":"Shahab Asgharzadeh","orcid":"0000-0002-0510-3848","position":16,"is_corresponding":false},{"id":1226341,"name":"JinSeok Park","orcid":"0009-0003-6432-6392","position":17,"is_corresponding":false},{"id":751251,"name":"W. Clay Gustafson","orcid":"0000-0002-1812-5675","position":18,"is_corresponding":false},{"id":558754,"name":"Katherine K. Matthay","orcid":"0000-0002-0146-2499","position":19,"is_corresponding":false},{"id":240511,"name":"John M. Maris","orcid":"0000-0002-8088-7929","position":20,"is_corresponding":false},{"id":351797,"name":"William A. Weiss","orcid":"0000-0003-2230-9132","position":21,"is_corresponding":false},{"id":911338,"name":"Miller Huang","orcid":"0000-0002-3371-0100","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T01:58:42.796720Z","pmid":"38451815","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}