{"doi":"10.1016/j.celrep.2024.113882","title":"Poxvirus A51R proteins regulate microtubule stability and antagonize a cell-intrinsic antiviral response","abstract":"Numerous viruses alter host microtubule (MT) networks during infection, but how and why they induce these changes is unclear in many cases. We show that the vaccinia virus (VV)-encoded A51R protein is a MT-associated protein (MAP) that directly binds MTs and stabilizes them by both promoting their growth and preventing their depolymerization. Furthermore, we demonstrate that A51R-MT interactions are conserved across A51R proteins from multiple poxvirus genera, and highly conserved, positively charged residues in A51R proteins mediate these interactions. Strikingly, we find that viruses encoding MT interaction-deficient A51R proteins fail to suppress a reactive oxygen species (ROS)-dependent antiviral response in macrophages that leads to a block in virion morphogenesis. Moreover, A51R-MT interactions are required for VV virulence in mice. Collectively, our data show that poxviral MAP-MT interactions overcome a cell-intrinsic antiviral ROS response in macrophages that would otherwise block virus morphogenesis and replication in animals.","journal":"Cell Reports","year":2024,"id":453438,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1170951,"name":"Sabrynna Brito Oliveira","orcid":"0000-0001-9303-4338","position":1,"is_corresponding":false},{"id":1041880,"name":"Emily A. Rex","orcid":"0000-0002-1057-3836","position":2,"is_corresponding":false},{"id":386468,"name":"Xuecheng Ye","orcid":null,"position":3,"is_corresponding":false},{"id":57571,"name":"Luke M. Rice","orcid":"0000-0001-6551-3307","position":4,"is_corresponding":false},{"id":91767,"name":"Flávio Guimarães da Fonseca","orcid":"0000-0002-1416-8694","position":5,"is_corresponding":false},{"id":1170953,"name":"Don B. Gammon","orcid":"0000-0003-1144-4152","position":6,"is_corresponding":false},{"id":1170950,"name":"Dahee Seo","orcid":"0009-0001-7813-9577","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-19T02:02:58.784290Z","pmid":"38457341","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}