{"doi":"10.1016/j.celrep.2024.113816","title":"Serine/arginine-rich splicing factor 7 promotes the type I interferon response by activating Irf7 transcription","abstract":"Tight regulation of macrophage immune gene expression is required to fight infection without risking harmful inflammation. The contribution of RNA-binding proteins (RBPs) to shaping the macrophage response to pathogens remains poorly understood. Transcriptomic analysis reveals that a member of the serine/arginine-rich (SR) family of mRNA processing factors, SRSF7, is required for optimal expression of a cohort of interferon-stimulated genes in macrophages. Using genetic and biochemical assays, we discover that in addition to its canonical role in regulating alternative splicing, SRSF7 drives transcription of interferon regulatory transcription factor 7 (IRF7) to promote antiviral immunity. At the Irf7 promoter, SRSF7 maximizes STAT1 transcription factor binding and RNA polymerase II elongation via cooperation with the H4K20me1 histone methyltransferase KMT5a (SET8). These studies define a role for an SR protein in activating transcription and reveal an RBP-chromatin network that orchestrates macrophage antiviral gene expression.","journal":"Cell Reports","year":2024,"id":424937,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1004320,"name":"Mackenzie H. Smith","orcid":"0000-0002-1698-1996","position":1,"is_corresponding":false},{"id":698216,"name":"Aja K. Coleman","orcid":"0000-0002-0916-4760","position":2,"is_corresponding":false},{"id":1222047,"name":"Kaitlyn S. Armijo","orcid":"0000-0003-2301-079X","position":3,"is_corresponding":false},{"id":1222048,"name":"Morgan J. Chapman","orcid":"0000-0003-1777-5227","position":4,"is_corresponding":false},{"id":1222551,"name":"Summer L. Apostalo","orcid":null,"position":5,"is_corresponding":false},{"id":698215,"name":"Allison R. Wagner","orcid":"0000-0002-6592-3741","position":6,"is_corresponding":false},{"id":270977,"name":"Robert O. Watson","orcid":"0000-0003-4976-0759","position":7,"is_corresponding":false},{"id":270976,"name":"Kristin L. Patrick","orcid":"0000-0003-2442-4679","position":8,"is_corresponding":false},{"id":698774,"name":"Haley M. Scott","orcid":null,"position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T01:58:21.523756Z","pmid":"38393946","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}