{"doi":"10.1016/j.celrep.2024.113763","title":"Identification of mebendazole as an ethylene signaling activator reveals a role of ethylene signaling in the regulation of lateral root angles","abstract":"The lateral root angle or gravitropic set-point angle (GSA) is an important trait for root system architecture (RSA) that determines the radial expansion of the root system. The GSA therefore plays a crucial role for the ability of plants to access nutrients and water in the soil. Only a few regulatory pathways and mechanisms that determine GSA are known. These mostly relate to auxin and cytokinin pathways. Here, we report the identification of a small molecule, mebendazole (MBZ), that modulates GSA in Arabidopsis thaliana roots and acts via the activation of ethylene signaling. MBZ directly acts on the serine/threonine protein kinase CTR1, which is a negative regulator of ethylene signaling. Our study not only shows that the ethylene signaling pathway is essential for GSA regulation but also identifies a small molecular modulator of RSA that acts downstream of ethylene receptors and that directly activates ethylene signaling.","journal":"Cell Reports","year":2024,"id":441904,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9594,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1255451,"name":"Hai An Truong","orcid":null,"position":1,"is_corresponding":false},{"id":567007,"name":"Ling Zhang","orcid":"0000-0001-5397-937X","position":2,"is_corresponding":false},{"id":834232,"name":"Min Cao","orcid":"0000-0001-5783-7029","position":3,"is_corresponding":false},{"id":1255452,"name":"Neal Arakawa","orcid":null,"position":4,"is_corresponding":false},{"id":565879,"name":"Yao Xiao","orcid":"0000-0002-8530-6177","position":5,"is_corresponding":false},{"id":1255453,"name":"Kaizhen Zhong","orcid":null,"position":6,"is_corresponding":false},{"id":1254944,"name":"Yingnan Hou","orcid":"0000-0002-6088-4632","position":7,"is_corresponding":false},{"id":249596,"name":"Wolfgang Busch","orcid":"0000-0003-2042-7290","position":8,"is_corresponding":false},{"id":1206903,"name":"Wenrong He","orcid":"0000-0003-1408-5327","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T02:01:11.152920Z","pmid":"38358890","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}