{"doi":"10.1016/j.celrep.2024.113703","title":"Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis","abstract":null,"journal":"Cell Reports","year":2024,"id":691383,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":452075,"name":"Junyi Xu","orcid":"0009-0007-7077-5767","position":1,"is_corresponding":false},{"id":1806488,"name":"Xuqing Shen","orcid":null,"position":2,"is_corresponding":false},{"id":370627,"name":"Jiajun Sun","orcid":null,"position":3,"is_corresponding":false},{"id":1494070,"name":"Mingzhu Liu","orcid":"0000-0002-9865-2239","position":4,"is_corresponding":false},{"id":1806489,"name":"Ningning Niu","orcid":null,"position":5,"is_corresponding":false},{"id":648966,"name":"Qidi Wang","orcid":null,"position":6,"is_corresponding":false},{"id":134819,"name":"Jing Xue","orcid":null,"position":7,"is_corresponding":false},{"id":284098,"name":"Ping Lu","orcid":"0000-0003-4593-327X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic organogenesis","abstract":"Pancreas development is tightly controlled by multilayer mechanisms. Despite years of effort, large gaps remain in understanding how histone modifications coordinate pancreas development. SETD2, a predominant histone methyltransferase of H3K36me3, plays a key role in embryonic stem cell differentiation, whose role in organogenesis remains elusive. Here, by combination of cleavage under targets and tagmentation (CUT&Tag), assay for transposase-accessible chromatin using sequencing (ATAC-seq), and bulk RNA sequencing, we show a dramatic increase in the H3K36me3 level from the secondary transition phase and decipher the related transcriptional alteration. Using single-cell RNA sequencing, we define that pancreatic deletion of Setd2 results in abnormalities in both exocrine and endocrine lineages: hyperproliferative tip progenitor cells lead to abnormal differentiation; Ngn3 + endocrine progenitors decline due to the downregulation of Nkx2.2 , leading to insufficient endocrine development. Thus, these data identify SETD2 as a crucial player in embryonic pancreas development, providing a clue to understanding the dysregulation of histone modifications in pancreatic disorders.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38265933","pmcid":null,"openalex_id":"https://openalex.org/W4391154509","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"32170826","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81770628","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81970553","title":null},{"funder_name":"Shanghai Municipal Education Commission","grant_id":"20161312","title":null},{"funder_name":"Innovative Research Team of High-level Local University in Shanghai","grant_id":"","title":null}],"total_grants":5,"fwci":2.8748,"citation_percentile":0.90217,"influential_citations":0,"citation_trend":[{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://doi.org/10.1016/j.celrep.2024.113703","host_type":"journal"},{"url":"https://doi.org/10.1016/j.celrep.2024.113703","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124724000317?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124724000317?httpAccept=text/plain","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38265933","host_type":"repository"},{"url":"https://doaj.org/article/e5023989db154b9bbce416c1d486e698","host_type":"repository"}],"fields_of_study":["Pancreatic function and diabetes","Genetics and Neurodevelopmental Disorders","Epigenetics and DNA Methylation"],"mesh_terms":["Animals","Cell Differentiation","Chromatin","Pancreas","Histone-Lysine N-Methyltransferase","Organogenesis","Mice"],"keywords":["Organogenesis","Biology","Cancer research","Cell biology","Genetics","Gene","histone modification","Epigenetics","Pancreas Development","Setd2","H3k36me3","Cp: Developmental Biology","Second Transition"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-30T20:18:33.153357Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}