{"doi":"10.1016/j.celrep.2024.113673","title":"TALK-1-mediated alterations of β-cell mitochondrial function and insulin secretion impair glucose homeostasis on a diabetogenic diet","abstract":"Mitochondrial Ca 2+ ([Ca 2+ ] m ) homeostasis is critical for β-cell function and becomes disrupted during the pathogenesis of diabetes. [Ca 2+ ] m uptake is dependent on elevations in cytoplasmic Ca 2+ ([Ca 2+ ] c ) and endoplasmic reticulum Ca 2+ ([Ca 2+ ] ER ) release, both of which are regulated by the two-pore domain K + channel TALK-1. Here, utilizing a novel β-cell TALK-1-knockout (β-TALK-1-KO) mouse model, we found that TALK-1 limited β-cell [Ca 2+ ] m accumulation and ATP production. However, following exposure to a high-fat diet (HFD), ATP-linked respiration, glucose-stimulated oxygen consumption rate, and glucose-stimulated insulin secretion (GSIS) were increased in control but not TALK1-KO mice. Although β-TALK-1-KO animals showed similar GSIS before and after HFD treatment, these mice were protected from HFD-induced glucose intolerance. Collectively, these data identify that TALK-1 channel control of β-cell function reduces [Ca 2+ ] m and suggest that metabolic remodeling in diabetes drives dysglycemia.","journal":"Cell Reports","year":2024,"id":429123,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1122345,"name":"Arya Y. Nakhe","orcid":"0000-0003-2192-5865","position":1,"is_corresponding":false},{"id":369839,"name":"Prasanna K. Dadi","orcid":"0000-0001-5377-5991","position":2,"is_corresponding":false},{"id":346921,"name":"Matthew T. Dickerson","orcid":"0000-0002-6187-3951","position":3,"is_corresponding":false},{"id":1231787,"name":"Jordyn R. Dobson","orcid":null,"position":4,"is_corresponding":false},{"id":345676,"name":"Karolina E. Zaborska","orcid":"0000-0003-1218-5228","position":5,"is_corresponding":false},{"id":1231788,"name":"Chloe E. Ibsen","orcid":null,"position":6,"is_corresponding":false},{"id":370583,"name":"Regan B. Butterworth","orcid":null,"position":7,"is_corresponding":false},{"id":658544,"name":"Nicholas C. Vierra","orcid":"0000-0001-7269-5399","position":8,"is_corresponding":false},{"id":345680,"name":"David A. Jacobson","orcid":"0000-0003-1816-5375","position":9,"is_corresponding":false},{"id":369840,"name":"Sarah M. Graff","orcid":"0000-0003-2408-3683","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T01:59:06.668462Z","pmid":"38206814","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}