{"doi":"10.1016/j.celrep.2023.113542","title":"CD62L expression marks a functionally distinct subset of memory B cells","abstract":"The memory B cell response consists of phenotypically distinct subsets that differ in their ability to respond upon antigen re-encounter. However, the pathways regulating the development and function of memory B cell subsets are poorly understood. Here, we show that CD62L and CD44 are progressively expressed on mouse memory B cells and identify transcriptionally and functionally distinct memory B cell subsets. Bcl6 is important in regulating memory B cell subset differentiation with overexpression of Bcl6 resulting in impaired CD62L + memory B cell development. Bcl6 regulates memory B cell subset development through control of a network of genes, including Bcl2 and Zeb2 . Overexpression of Zeb2 impairs the development of CD62L + memory B cells. Importantly, CD62L is also differentially expressed on human memory B cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and identifies phenotypically distinct populations. Together, these data indicate that CD62L expression marks functionally distinct memory B cell subsets.","journal":"Cell Reports","year":2023,"id":341956,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":570290,"name":"Brittany Henry","orcid":"0000-0003-0753-8519","position":1,"is_corresponding":false},{"id":1077999,"name":"Pradhnesh Andhare","orcid":"0000-0003-2207-8821","position":2,"is_corresponding":false},{"id":943834,"name":"Frank J. Lin","orcid":null,"position":3,"is_corresponding":false},{"id":1078459,"name":"Haley Pak","orcid":null,"position":4,"is_corresponding":false},{"id":225532,"name":"Jackson S. Turner","orcid":"0000-0002-4396-6265","position":5,"is_corresponding":false},{"id":246334,"name":"Lucas J. Adams","orcid":"0000-0002-1724-8120","position":6,"is_corresponding":false},{"id":340666,"name":"Tom Liu","orcid":null,"position":7,"is_corresponding":false},{"id":225534,"name":"Daved H. Fremont","orcid":"0000-0002-8544-2689","position":8,"is_corresponding":false},{"id":225537,"name":"Ali H. Ellebedy","orcid":"0000-0002-6129-2532","position":9,"is_corresponding":false},{"id":560220,"name":"Brian J. Laidlaw","orcid":"0000-0001-5707-9256","position":10,"is_corresponding":false},{"id":943835,"name":"Christopher H. Hanson","orcid":null,"position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T01:11:08.077724Z","pmid":"38060451","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}