{"doi":"10.1016/j.celrep.2023.113508","title":"IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis","abstract":null,"journal":"Cell Reports","year":2023,"id":635014,"datarank":0.3958585994422889,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.0,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1604390,"name":"Lucía Sancho-Temiño","orcid":null,"position":1,"is_corresponding":false},{"id":1647238,"name":"Raquel Castillo-González","orcid":null,"position":2,"is_corresponding":false},{"id":1647239,"name":"Cristina Villa-Gómez","orcid":null,"position":3,"is_corresponding":false},{"id":1647240,"name":"María José Gomez-Sánchez","orcid":null,"position":4,"is_corresponding":false},{"id":1647241,"name":"Anne Ochoa-Ramos","orcid":null,"position":5,"is_corresponding":false},{"id":1647242,"name":"Patricia Yagüe-Fernández","orcid":null,"position":6,"is_corresponding":false},{"id":1647244,"name":"Blanca Soler Palacios","orcid":null,"position":7,"is_corresponding":false},{"id":245950,"name":"Virginia Zorita","orcid":"0009-0003-1527-9737","position":8,"is_corresponding":false},{"id":1647246,"name":"Berta Raposo-Ponce","orcid":null,"position":9,"is_corresponding":false},{"id":1647248,"name":"José María González-Granado","orcid":null,"position":10,"is_corresponding":false},{"id":1647250,"name":"Julián Aragonés","orcid":null,"position":11,"is_corresponding":false},{"id":1647253,"name":"Aránzazu Cruz-Adalia","orcid":null,"position":12,"is_corresponding":false},{"id":1647235,"name":"Ana Valle-Noguera","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"IL-18-induced HIF-1α in ILC3s ameliorates the inflammation of C. rodentium-induced colitis","abstract":"Group 3 innate lymphoid cells (ILC3s) are vital for defending tissue barriers from invading pathogens. Hypoxia influences the production of intestinal ILC3-derived cytokines by activating HIF. Yet, the mechanisms governing HIF-1α in ILC3s and other innate RORγt+ cells during in vivo infections are poorly understood. In our study, transgenic mice with specific Hif-1a gene inactivation in innate RORγt+ cells (RAG1KO HIF-1α▵Rorc) exhibit more severe colitis following Citrobacter rodentium infection, primarily due to the inability to upregulate IL-22. We find that HIF-1α▵Rorc mice have impaired IL-22 production in ILC3s, while non-ILC3 innate RORγt+ cells, also capable of producing IL-22, remain unaffected. Furthermore, we show that IL-18, induced by Toll-like receptor 2, selectively triggers IL-22 in ILC3s by transcriptionally upregulating HIF-1α, revealing an oxygen-independent regulatory pathway. Our results highlight that, during late-stage C. rodentium infection, IL-18 induction in the colon promotes IL-22 through HIF-1α in ILC3s, which is crucial for protection against this pathogen.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38019650","pmcid":null,"openalex_id":"https://openalex.org/W4389111240","authors":[],"funders":[{"funder_name":"Centro Nacional de Biotecnología","grant_id":"RYC- 2017-21837","title":null},{"funder_name":"Centro Nacional de Biotecnología","grant_id":"CNS2022-135365","title":null},{"funder_name":"Centro Nacional de Biotecnología","grant_id":"RTI2018-093647-B-I00","title":null},{"funder_name":"Centro Nacional de Biotecnología","grant_id":"PID2021-122780OB-I00","title":null},{"funder_name":"European Regional Development Fund","grant_id":"FJC2021-047282-I","title":null},{"funder_name":"European Regional Development Fund","grant_id":"09-PIN1-00009.8/2022","title":null},{"funder_name":"European Regional Development Fund","grant_id":"FPU22/02155","title":null},{"funder_name":"European Regional Development Fund","grant_id":"PRE2019-090341","title":null},{"funder_name":"Instituto de Salud Carlos III","grant_id":"PI20/00306","title":null},{"funder_name":"Agencia Estatal de Investigación","grant_id":"","title":null},{"funder_name":"Ministerio de Educación y Formación Profesional","grant_id":"","title":null},{"funder_name":"Ministerio de Ciencia e Innovación","grant_id":"","title":null},{"funder_name":"DST-NRF Centre of Excellence for Invasion Biology","grant_id":"","title":null},{"funder_name":"Comunidad de Madrid","grant_id":"","title":null},{"funder_name":"España Ministerio de Ciencia e Innovación","grant_id":"","title":null}],"total_grants":15,"fwci":0.9993,"citation_percentile":0.75378944,"influential_citations":0,"citation_trend":[{"year":2024,"count":6},{"year":2025,"count":4},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://ars.els-cdn.com/content/image/1-s2.0-S2211124723015206-fx1_lrg.jpg","host_type":"journal"},{"url":"https://ars.els-cdn.com/content/image/1-s2.0-S2211124723015206-fx1_lrg.jpg","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124723015206?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124723015206?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2023.113508","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38019650","host_type":"repository"},{"url":"http://hdl.handle.net/10261/341529","host_type":"repository"},{"url":"http://hdl.handle.net/10261/347507","host_type":"repository"},{"url":"https://doaj.org/article/5b260e4b11834ac38bde4e1b0ddc5764","host_type":"repository"}],"fields_of_study":["IL-33, ST2, and ILC Pathways","Immune Cell Function and Interaction","Eosinophilic Esophagitis","Mice","Animals","Interleukins","Immunity, Innate","Nuclear Receptor Subfamily 1, Group F, Member 3","Lymphocytes","Interleukin-18","Colitis","Inflammation","Mice, Transgenic","Mice, Inbred C57BL"],"mesh_terms":["Animals","Colitis","Immunity, Innate","Inflammation","Interleukins","Lymphocytes","Mice, Inbred C57BL","Mice, Transgenic","Interleukin-18","Mice","Nuclear Receptor Subfamily 1, Group F, Member 3"],"keywords":["RAR-related orphan receptor gamma","Citrobacter rodentium","Innate lymphoid cell","Biology","Immunology","Inflammation","Innate immune system","Colitis","Downregulation and upregulation","Cell biology","Immune system","Biochemistry","Infection","TLR2","HIF-1α","IL-18","Il-22","Group 3 Innate Lymphoid Cells","Cp: Immunology","Innate Rorγt(+) Cells"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T14:32:19.879940Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}