{"doi":"10.1016/j.celrep.2023.113450","title":"High frequency of HIV precursor-target-specific B cells in sub-Saharan populations","abstract":"HIV gp120 engineered outer domain germline-targeting version 8 (eOD-GT8) was designed specifically to engage naive B cell precursors of VRC01-class antibodies. However, the frequency and affinity of naive B cell precursors able to recognize eOD-GT8 have been evaluated only in U.S. populations. HIV infection is disproportionally concentrated in sub-Saharan Africa, so we seek to characterize naive B cells able to recognize eOD-GT8 in sub-Saharan cohorts. We demonstrate that people from sub-Saharan Africa have a higher or equivalent frequency of naive B cells able to engage eOD-GT8 compared with people from the U.S. Genetically, the higher frequency of eOD-GT8-positive cells is accompanied by a higher level of naive B cells with gene signatures characteristic of the VRC01 class, as well as other CD4bs-directed antibodies. Our study demonstrates that vaccination with eOD-GT8 in sub-Saharan Africa could be successful at expanding and establishing a pool of CD4bs-directed memory B cells from naive precursors.","journal":"Cell Reports","year":2023,"id":376114,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":522236,"name":"Alberto Cagigi","orcid":"0000-0002-3567-9514","position":1,"is_corresponding":false},{"id":390894,"name":"Chen‐Hsiang Shen","orcid":"0000-0002-9560-3992","position":2,"is_corresponding":false},{"id":619541,"name":"Amy R. Henry","orcid":null,"position":3,"is_corresponding":false},{"id":266258,"name":"Timothy S. Johnston","orcid":"0000-0001-9246-6155","position":4,"is_corresponding":false},{"id":283220,"name":"Chaim A. Schramm","orcid":null,"position":5,"is_corresponding":false},{"id":284395,"name":"Christopher A. Cottrell","orcid":"0000-0002-3364-3083","position":6,"is_corresponding":false},{"id":842718,"name":"Oleksandr Kalyuzhniy","orcid":"0000-0002-5273-1951","position":7,"is_corresponding":false},{"id":807086,"name":"Abby Spangler","orcid":"0000-0002-0028-9348","position":8,"is_corresponding":false},{"id":252002,"name":"Thumbi Ndung’u","orcid":"0000-0003-2962-3992","position":9,"is_corresponding":false},{"id":252000,"name":"Krista L. Dong","orcid":"0000-0002-2038-3518","position":10,"is_corresponding":false},{"id":531355,"name":"Leigh Eller","orcid":null,"position":11,"is_corresponding":false},{"id":288619,"name":"Merlin L. Robb","orcid":"0000-0003-3949-9649","position":12,"is_corresponding":false},{"id":332556,"name":"Michael A. Eller","orcid":"0000-0003-3905-4877","position":13,"is_corresponding":false},{"id":997383,"name":"Prossy Naluyima","orcid":"0000-0001-6911-2199","position":14,"is_corresponding":false},{"id":105633,"name":"Peter D. Kwong","orcid":"0000-0003-3560-232X","position":15,"is_corresponding":false},{"id":277153,"name":"Daniel C. Douek","orcid":"0000-0001-5575-8634","position":16,"is_corresponding":false},{"id":236279,"name":"William R. Schief","orcid":"0000-0002-1120-0150","position":17,"is_corresponding":false},{"id":340056,"name":"Sarah F. Andrews","orcid":"0000-0002-2583-1949","position":18,"is_corresponding":false},{"id":218075,"name":"Adrian B. McDermott","orcid":"0000-0003-0616-9117","position":19,"is_corresponding":false},{"id":1071458,"name":"Flavio Matassoli","orcid":"0009-0000-5559-8781","position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T01:16:28.318749Z","pmid":"38019653","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}