{"doi":"10.1016/j.celrep.2023.113449","title":"Keratinocyte FABP5-VCP complex mediates recruitment of neutrophils in psoriasis","abstract":"One of the hallmarks of intractable psoriasis is neutrophil infiltration in skin lesions. However, detailed molecular mechanisms of neutrophil chemotaxis and activation remain unclear. Here, we demonstrate a significant upregulation of epidermal fatty acid binding protein (E-FABP, FABP5) in the skin of human psoriasis and psoriatic mouse models. Genetic deletion of FABP5 in mice by global knockout and keratinocyte conditional (Krt6a-Cre) knockout, but not myeloid cell conditional (LysM-Cre) knockout, attenuates psoriatic symptoms. Immunophenotypic analysis shows that FABP5 deficiency specifically reduces skin recruitment of Ly6G + neutrophils. Mechanistically, activated keratinocytes produce chemokines and cytokines that trigger neutrophil chemotaxis and activation in an FABP5-dependent manner. Proteomic analysis further identifies that FABP5 interacts with valosin-containing protein (VCP), a key player in NF-κB signaling activation. Silencing of FABP5, VCP, or both inhibits NF-κB/neutrophil chemotaxis signaling. Collectively, these data demonstrate dysregulated FABP5 as a molecular mechanism promoting NF-κB signaling and neutrophil infiltration in psoriasis pathogenesis.","journal":"Cell Reports","year":2023,"id":327103,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":763558,"name":"Jianyu Yu","orcid":"0000-0002-1856-2189","position":1,"is_corresponding":false},{"id":896238,"name":"Matthew S. Yorek","orcid":"0000-0002-4737-9367","position":2,"is_corresponding":false},{"id":812011,"name":"Chi-Li Yu","orcid":null,"position":3,"is_corresponding":false},{"id":604515,"name":"R. Marshall Pope","orcid":"0000-0001-9584-3876","position":4,"is_corresponding":false},{"id":86083,"name":"Michael S. Chimenti","orcid":"0000-0002-4433-9976","position":5,"is_corresponding":false},{"id":1047159,"name":"Yiqin Xiong","orcid":"0000-0003-4138-5851","position":6,"is_corresponding":false},{"id":413575,"name":"Aloysius J. Klingelhutz","orcid":"0000-0003-4258-5046","position":7,"is_corresponding":false},{"id":454548,"name":"Ali Jabbari","orcid":"0000-0002-8559-7314","position":8,"is_corresponding":false},{"id":256400,"name":"Bing Li","orcid":"0000-0001-5363-7070","position":9,"is_corresponding":false},{"id":256401,"name":"Jiaqing Hao","orcid":"0000-0002-2834-7255","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T01:08:42.846627Z","pmid":"37967009","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}