{"doi":"10.1016/j.celrep.2023.113433","title":"Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch","abstract":null,"journal":"Cell Reports","year":2023,"id":602933,"datarank":0.6261580904843456,"base_score":4.174387269895637,"endowment":4.174387269895637,"self_citation_contribution":0.6261580904843456,"citation_network_contribution":0.0,"self_endowment_contribution":0.6261580904843456,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1546553,"name":"Sotaro Ochiai","orcid":null,"position":1,"is_corresponding":false},{"id":1546554,"name":"Jianshi Jin","orcid":null,"position":2,"is_corresponding":false},{"id":940131,"name":"Noriko Takahashi","orcid":"0000-0003-1025-1690","position":3,"is_corresponding":false},{"id":1546555,"name":"Susumu Toshima","orcid":null,"position":4,"is_corresponding":false},{"id":1546556,"name":"Harumichi Ishigame","orcid":null,"position":5,"is_corresponding":false},{"id":313401,"name":"Kenji Kabashima","orcid":"0000-0002-0773-0554","position":6,"is_corresponding":false},{"id":622315,"name":"Masato Kubo","orcid":null,"position":7,"is_corresponding":false},{"id":1546557,"name":"Manabu Nakayama","orcid":null,"position":8,"is_corresponding":false},{"id":1546558,"name":"Katsuyuki Shiroguchi","orcid":null,"position":9,"is_corresponding":false},{"id":901587,"name":"Takaharu Okada","orcid":"0000-0002-4784-5145","position":10,"is_corresponding":false},{"id":1546552,"name":"Sonoko Takahashi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch","abstract":"IL-31 receptor blockade suppresses pruritus of atopic dermatitis. However, cell-type-specific contributions of IL-31 receptor to itch, its expression mechanism, and the downstream signaling pathway to induce itch remain unknown. Here, using conditional knockout mice, we demonstrate that IL-31-induced itch requires sensory neuronal IL-31 receptor and STAT3. We find that IL-31 receptor expression is dependent on STAT3 in sensory neurons. In addition, pharmacological experiments suggest that STAT3 activation is important for the itch-inducing signaling downstream of the IL-31 receptor. A cutaneous IL-31 injection induces the nuclear accumulation of activated STAT3 first in sensory neurons that abundantly express IL-31 receptor and then in other itch-transmitting neurons. IL-31 enhances itch induced by various pruritogens including even chloroquine. Finally, pruritus associated with dermatitis is partially dependent on sensory neuronal IL-31 receptor and strongly on sensory neuronal STAT3. Thus, sensory neuronal STAT3 is essential for IL-31-induced itch and further contributes to IL-31-independent inflammatory itch.","is_dataset_classified":null,"base_score":4.127134385045092,"endowment":4.127134385045092,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38029739","pmcid":null,"openalex_id":"https://openalex.org/W4389101128","authors":[],"funders":[{"funder_name":"Japan Science and Technology Agency","grant_id":"JPMJCR17H1","title":null},{"funder_name":"Japan Science and Technology Agency","grant_id":"JPMJMS2025","title":null},{"funder_name":"Core Research for Evolutional Science and Technology","grant_id":"JP23gm1210006","title":null},{"funder_name":"Core Research for Evolutional Science and Technology","grant_id":"JP21am0101119","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"18H05411","title":null},{"funder_name":"Japan Agency for Medical Research and Development","grant_id":"","title":null},{"funder_name":"RIKEN","grant_id":"","title":null}],"total_grants":7,"fwci":14.2351,"citation_percentile":0.99244706,"influential_citations":0,"citation_trend":[{"year":2024,"count":10},{"year":2025,"count":24},{"year":2026,"count":27}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.cell.com/article/S2211124723014456/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2211124723014456/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124723014456?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124723014456?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2023.113433","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38029739","host_type":"repository"}],"fields_of_study":["Dermatology and Skin Diseases","T-cell and B-cell Immunology","Herbal Medicine Research Studies"],"mesh_terms":["Animals","Dermatitis, Atopic","Pruritus","Sensory Receptor Cells","Skin","Gene Expression","Mice, Knockout","Ubiquitin-Protein Ligases","STAT3 Transcription Factor","Mice"],"keywords":["Receptor","Sensory system","STAT3","Signal transduction","Sensory receptor","Neuroscience","Biology","Medicine","Immunology","Cell biology","Internal medicine","Keratinocytes","Pruritus","Atopic Dermatitis","Itch","Il-31","Sensory Neurons","Cp: Neuroscience","Cp: Immunology"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T20:41:05.868998Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}