{"doi":"10.1016/j.celrep.2023.113380","title":"Integrative single-cell meta-analysis reveals disease-relevant vascular cell states and markers in human atherosclerosis","abstract":"Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the arterial wall. CAD progression involves complex interactions and phenotypic plasticity among vascular and immune cell lineages. Single-cell RNA-seq (scRNA-seq) studies have highlighted lineage-specific transcriptomic signatures, but human cell phenotypes remain controversial. Here, we perform an integrated meta-analysis of 22 scRNA-seq libraries to generate a comprehensive map of human atherosclerosis with 118,578 cells. Besides characterizing granular cell-type diversity and communication, we leverage this atlas to provide insights into smooth muscle cell (SMC) modulation. We integrate genome-wide association study data and uncover a critical role for modulated SMC phenotypes in CAD, myocardial infarction, and coronary calcification. Finally, we identify fibromyocyte/fibrochondrogenic SMC markers (LTBP1 and CRTAC1) as proxies of atherosclerosis progression and validate these through omics and spatial imaging analyses. Altogether, we create a unified atlas of human atherosclerosis informing cell state-specific mechanistic and translational studies of cardiovascular diseases.","journal":"Cell Reports","year":2023,"id":316291,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":109,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8818,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":298086,"name":"Gaëlle Auguste","orcid":"0000-0003-4900-6959","position":1,"is_corresponding":false},{"id":558978,"name":"Doris Wong","orcid":"0000-0002-1094-8677","position":2,"is_corresponding":false},{"id":236711,"name":"Adam W. Turner","orcid":"0000-0002-3087-9939","position":3,"is_corresponding":false},{"id":441470,"name":"Chani J. Hodonsky","orcid":"0000-0001-8566-5877","position":4,"is_corresponding":false},{"id":1019724,"name":"Astrid Catalina Álvarez-Yela","orcid":"0000-0002-2911-1690","position":5,"is_corresponding":false},{"id":558979,"name":"Yipei Song","orcid":"0009-0004-4906-3026","position":6,"is_corresponding":false},{"id":1019725,"name":"Qi Cheng","orcid":"0000-0002-2107-6253","position":7,"is_corresponding":false},{"id":329879,"name":"Christian L. Lino Cardenas","orcid":"0000-0001-5491-4375","position":8,"is_corresponding":false},{"id":860624,"name":"Konstantinos Theofilatos","orcid":"0000-0001-6799-0553","position":9,"is_corresponding":false},{"id":986535,"name":"Maxime M. Bos","orcid":"0000-0001-5028-4820","position":10,"is_corresponding":false},{"id":38804,"name":"Maryam Kavousi","orcid":"0000-0001-5976-6519","position":11,"is_corresponding":false},{"id":25005,"name":"Patricia A. Peyser","orcid":"0000-0002-9717-8459","position":12,"is_corresponding":false},{"id":282922,"name":"Manuel Mayr","orcid":"0000-0002-0597-829X","position":13,"is_corresponding":false},{"id":245353,"name":"Jason C. Kovacic","orcid":"0000-0003-4555-769X","position":14,"is_corresponding":false},{"id":236716,"name":"Johan Björkegren","orcid":"0000-0003-1945-7425","position":15,"is_corresponding":false},{"id":109286,"name":"Rajeev Malhotra","orcid":"0000-0003-0120-4630","position":16,"is_corresponding":false},{"id":725828,"name":"P. Todd Stukenberg","orcid":"0000-0002-6788-2111","position":17,"is_corresponding":false},{"id":235795,"name":"Aloke V. Finn","orcid":"0000-0003-0359-0184","position":18,"is_corresponding":false},{"id":21722,"name":"Sander W. van der Laan","orcid":"0000-0001-6888-1404","position":19,"is_corresponding":false},{"id":43221,"name":"Chongzhi Zang","orcid":"0000-0003-4812-3627","position":20,"is_corresponding":false},{"id":11628,"name":"Nathan C. 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