{"doi":"10.1016/j.celrep.2023.113371","title":"Integration of transcriptomes of senescent cell models with multi-tissue patient samples reveals reduced COL6A3 as an inducer of senescence","abstract":"Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction, but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue-relevant senescence biology, we integrate the transcriptomes of 10 experimental senescence cell models with a 224 multi-tissue gene co-expression network based on RNA-seq data of seven tissues biopsies from ∼600 coronary artery disease (CAD) patients. We identify 56 senescence-associated modules, many enriched in CAD GWAS genes and correlated with cardiometabolic traits-which supports universality of senescence gene programs across tissues and in CAD. Cross-tissue network analyses reveal 86 candidate senescence-associated secretory phenotype (SASP) factors, including COL6A3. Experimental knockdown of COL6A3 induces transcriptional changes that overlap the majority of the experimental senescence models, with cell-cycle arrest linked to modulation of DREAM complex-targeted genes. We provide a transcriptomic resource for cellular senescence and identify candidate biomarkers, SASP factors, and potential drivers of senescence in human tissues.","journal":"Cell Reports","year":2023,"id":328771,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7021,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":32790,"name":"Jialiang Yang","orcid":"0000-0003-4689-8672","position":1,"is_corresponding":false},{"id":64661,"name":"Simon Koplev","orcid":"0000-0002-8586-5614","position":2,"is_corresponding":false},{"id":1051354,"name":"Mahru C. An","orcid":null,"position":3,"is_corresponding":false},{"id":1051355,"name":"Priyanka L. Patel","orcid":null,"position":4,"is_corresponding":false},{"id":796084,"name":"Robert O’Brien","orcid":"0000-0002-3611-1648","position":5,"is_corresponding":false},{"id":622316,"name":"Brittany N. Dubose","orcid":null,"position":6,"is_corresponding":false},{"id":470524,"name":"Tetyana Dodatko","orcid":null,"position":7,"is_corresponding":false},{"id":640977,"name":"Eduard Rogatsky","orcid":"0000-0001-6786-5242","position":8,"is_corresponding":false},{"id":382834,"name":"Katyayani Sukhavasi","orcid":"0000-0001-5627-0163","position":9,"is_corresponding":false},{"id":382833,"name":"Raili Ermel","orcid":"0000-0002-2726-2364","position":10,"is_corresponding":false},{"id":382835,"name":"Arno Ruusalepp","orcid":"0000-0001-5816-8613","position":11,"is_corresponding":false},{"id":266343,"name":"Sander M. Houten","orcid":"0000-0002-6167-9147","position":12,"is_corresponding":false},{"id":245353,"name":"Jason C. Kovacic","orcid":"0000-0003-4555-769X","position":13,"is_corresponding":false},{"id":310886,"name":"Andrew F. Stewart","orcid":"0000-0001-7866-5959","position":14,"is_corresponding":false},{"id":229146,"name":"Christopher B. Yohn","orcid":"0000-0002-5937-8070","position":15,"is_corresponding":false},{"id":5797,"name":"Eric E. Schadt","orcid":"0000-0002-7892-8808","position":16,"is_corresponding":false},{"id":229147,"name":"Rémi-Martin Laberge","orcid":"0000-0002-5841-5781","position":17,"is_corresponding":false},{"id":236716,"name":"Johan Björkegren","orcid":"0000-0003-1945-7425","position":18,"is_corresponding":false},{"id":32787,"name":"Zhidong Tu","orcid":"0000-0001-7721-1410","position":19,"is_corresponding":false},{"id":5805,"name":"Carmen Argmann","orcid":"0000-0002-1110-8012","position":20,"is_corresponding":false},{"id":599864,"name":"Radoslav Savić","orcid":"0000-0002-2670-3674","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T01:08:56.940647Z","pmid":"37938972","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}