{"doi":"10.1016/j.celrep.2023.113323","title":"Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation","abstract":"Intestinal colonization by antigenically foreign microbes necessitates expanded peripheral immune tolerance. Here we show commensal microbiota prime expansion of CD4 T cells unified by the Kruppel-like factor 2 (KLF2) transcriptional regulator and an essential role for KLF2+ CD4 cells in averting microbiota-driven intestinal inflammation. CD4 cells with commensal specificity in secondary lymphoid organs and intestinal tissues are enriched for KLF2 expression, and distinct from FOXP3+ regulatory T cells or other differentiation lineages. Mice with conditional KLF2 deficiency in T cells develop spontaneous rectal prolapse and intestinal inflammation, phenotypes overturned by eliminating microbiota or reconstituting with donor KLF2+ cells. Activated KLF2+ cells selectively produce IL-10, and eliminating IL-10 overrides their suppressive function in vitro and protection against intestinal inflammation in vivo. Together with reduced KLF2+ CD4 cell accumulation in Crohn's disease, a necessity for the KLF2+ subpopulation of T regulatory type 1 (Tr1) cells in sustaining commensal tolerance is demonstrated.","journal":"Cell Reports","year":2023,"id":351880,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9419,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1096937,"name":"Tony T. Jiang","orcid":"0000-0003-4979-0974","position":1,"is_corresponding":false},{"id":830395,"name":"Joseph Stevens","orcid":"0000-0002-2691-5765","position":2,"is_corresponding":false},{"id":1039073,"name":"Abigail E. Russi","orcid":"0000-0003-4725-2574","position":3,"is_corresponding":false},{"id":80480,"name":"Ty D. Troutman","orcid":"0000-0001-8925-8080","position":4,"is_corresponding":false},{"id":895858,"name":"Anas Bernieh","orcid":null,"position":5,"is_corresponding":false},{"id":273729,"name":"Giang Pham","orcid":"0000-0002-2926-7759","position":6,"is_corresponding":false},{"id":536810,"name":"John J. Erickson","orcid":"0000-0001-6189-9302","position":7,"is_corresponding":false},{"id":640691,"name":"Emily M. Eshleman","orcid":"0000-0003-4828-4105","position":8,"is_corresponding":false},{"id":39745,"name":"Theresa Alenghat","orcid":"0000-0003-4514-3710","position":9,"is_corresponding":false},{"id":235915,"name":"Stephen C. Jameson","orcid":"0000-0001-9137-1146","position":10,"is_corresponding":false},{"id":235914,"name":"Kristin A. Hogquist","orcid":"0000-0001-9963-5687","position":11,"is_corresponding":false},{"id":249182,"name":"Casey T. Weaver","orcid":"0000-0002-2180-1793","position":12,"is_corresponding":false},{"id":302643,"name":"David Haslam","orcid":"0000-0002-2143-5869","position":13,"is_corresponding":false},{"id":302692,"name":"Hitesh Deshmukh","orcid":"0000-0001-9632-164X","position":14,"is_corresponding":false},{"id":270438,"name":"Sing Sing Way","orcid":"0000-0001-8948-1952","position":15,"is_corresponding":false},{"id":302642,"name":"Tzu‐Yu Shao","orcid":"0000-0002-2896-689X","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-19T01:12:45.897709Z","pmid":"37889750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}