{"doi":"10.1016/j.celrep.2023.113273","title":"m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation","abstract":null,"journal":"Cell Reports","year":2023,"id":644584,"datarank":0.974159125213441,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.45429873979348184,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.45429873979348184,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":29,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":642112,"name":"Shi Liu","orcid":"0000-0002-1182-975X","position":1,"is_corresponding":false},{"id":1487358,"name":"Qingyu Luo","orcid":"0000-0003-4164-637X","position":2,"is_corresponding":false},{"id":1487359,"name":"Xiaowei Wu","orcid":"0000-0003-4176-7198","position":3,"is_corresponding":false},{"id":143296,"name":"Pengfei Zhao","orcid":null,"position":4,"is_corresponding":false},{"id":1904,"name":"Wan Chang","orcid":null,"position":5,"is_corresponding":false},{"id":1677891,"name":"Ruixiang Zhang","orcid":null,"position":6,"is_corresponding":false},{"id":32289,"name":"Yin Li","orcid":"0000-0003-4911-9208","position":7,"is_corresponding":false},{"id":314274,"name":"Zhihua Liu","orcid":"0000-0003-4242-033X","position":8,"is_corresponding":false},{"id":1363364,"name":"Yabing Nan","orcid":"0000-0001-8744-9617","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation","abstract":"RNA N 6 -methyladenosine (m 6 A) modification is implicated in cancer progression, yet its role in regulating long noncoding RNAs during cancer progression remains unclear. Here, we report that the m 6 A demethylase fat mass and obesity-associated protein (FTO) stabilizes long intergenic noncoding RNA for kinase activation (LINK-A) to promote cell proliferation and chemoresistance in esophageal squamous cell carcinoma (ESCC). Mechanistically, LINK-A promotes the interaction between minichromosome maintenance complex component 3 (MCM3) and cyclin-dependent kinase 1 (CDK1), increasing MCM3 phosphorylation. This phosphorylation facilitates the loading of the MCM complex onto chromatin, which promotes cell-cycle progression and subsequent cell proliferation. Moreover, LINK-A disrupts the interaction between MCM3 and hypoxia-inducible factor 1α (HIF-1α), abrogating MCM3-mediated HIF-1α transcriptional repression and promoting glycolysis and chemoresistance. These results elucidate the mechanism by which FTO-stabilized LINK-A plays oncogenic roles and identify the FTO/LINK-A/MCM3/HIF-1α axis as a promising therapeutic target for ESCC.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37858471","pmcid":null,"openalex_id":"https://openalex.org/W4387784013","authors":[],"funders":[{"funder_name":"Chinese Academy of Meteorological Sciences","grant_id":"3332021091","title":null},{"funder_name":"CAMS Innovation Fund for Medical Sciences","grant_id":"2021-I2 M-1-018","title":null},{"funder_name":"CAMS Innovation Fund for Medical Sciences","grant_id":"2021-I2 M-1-067","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"3332022135","title":null},{"funder_name":"National Key Research and Development Program of China Stem Cell and Translational Research","grant_id":"2021YFC2501000","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82030089","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82172590","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"82188102","title":null},{"funder_name":"National Cancer Center","grant_id":"","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"","title":null},{"funder_name":"National Key Research and Development Program of China","grant_id":"","title":null},{"funder_name":"Leukemia and Lymphoma Society","grant_id":"","title":null}],"total_grants":12,"fwci":2.6796,"citation_percentile":0.91426334,"influential_citations":0,"citation_trend":[{"year":2024,"count":8},{"year":2025,"count":8},{"year":2026,"count":13}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"http://www.cell.com/article/S2211124723012858/pdf","host_type":"journal"},{"url":"http://www.cell.com/article/S2211124723012858/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124723012858?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124723012858?httpAccept=text/plain","host_type":"publisher"},{"url":"https://doi.org/10.1016/j.celrep.2023.113273","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37858471","host_type":"repository"},{"url":"https://doaj.org/article/132987e3ed714f70ac45422af6839824","host_type":"repository"}],"fields_of_study":["RNA modifications and cancer","Cancer-related molecular mechanisms research","Cancer-related gene regulation"],"mesh_terms":["Alpha-Ketoglutarate-Dependent Dioxygenase FTO","Esophageal Squamous Cell Carcinoma","Cell Nucleus","Esophageal Neoplasms","Humans","Cell Line, Tumor","Cell Proliferation","Hypoxia-Inducible Factor 1, alpha Subunit","Minichromosome Maintenance Complex Component 3"],"keywords":["Cell biology","Cell cycle","Biology","Cell growth","Demethylase","Cancer research","Chromatin","Cyclin-dependent kinase 1","Phosphorylation","Cell","Histone","Gene","Biochemistry","Cell cycle progression","HIF-1α","esophageal squamous cell carcinoma","glycolysis","Chemoresistance","Cdk1","Fto","Mcm3","Cp: Cancer","M(6)a","Link-a"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T01:36:44.804412Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}