{"doi":"10.1016/j.celrep.2023.113233","title":"Hadza Prevotella require diet-derived microbiota-accessible carbohydrates to persist in mice","abstract":"Industrialization has transformed the gut microbiota, reducing the prevalence of Prevotella relative to Bacteroides . Here, we isolate Bacteroides and Prevotella strains from the microbiota of Hadza hunter-gatherers in Tanzania, a population with high levels of Prevotella . We demonstrate that plant-derived microbiota-accessible carbohydrates (MACs) are required for persistence of Prevotella copri but not Bacteroides thetaiotaomicron in vivo . Differences in carbohydrate metabolism gene content, expression, and in vitro growth reveal that Hadza Prevotella strains specialize in degrading plant carbohydrates, while Hadza Bacteroides isolates use both plant and host-derived carbohydrates, a difference mirrored in Bacteroides from non-Hadza populations. When competing directly, P. copri requires plant-derived MACs to maintain colonization in the presence of B. thetaiotaomicron , as a no-MAC diet eliminates P. copri colonization. Prevotella 's reliance on plant-derived MACs and Bacteroides ' ability to use host mucus carbohydrates could explain the reduced prevalence of Prevotella in populations consuming a low-MAC, industrialized diet.","journal":"Cell Reports","year":2023,"id":326323,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9601,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":36385,"name":"Matthew R. Olm","orcid":"0000-0001-5540-350X","position":1,"is_corresponding":false},{"id":661841,"name":"Nicolas Terrapon","orcid":"0000-0002-3693-6017","position":2,"is_corresponding":false},{"id":1045266,"name":"Fatima Enam","orcid":"0000-0001-8812-2026","position":3,"is_corresponding":false},{"id":258812,"name":"Steven K. Higginbottom","orcid":"0000-0002-4609-6840","position":4,"is_corresponding":false},{"id":36353,"name":"Justin L. Sonnenburg","orcid":"0000-0003-2299-6817","position":5,"is_corresponding":false},{"id":237037,"name":"Erica D. Sonnenburg","orcid":"0000-0001-8379-005X","position":6,"is_corresponding":false},{"id":985814,"name":"Rebecca Gellman","orcid":"0000-0002-0795-3125","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"38510311","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}