{"doi":"10.1016/j.celrep.2023.113180","title":"Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells","abstract":"Cognate interaction between CD4 + effector memory T (T EM ) cells and dendritic cells (DCs) induces innate inflammatory cytokine production, resulting in detrimental autoimmune pathology and cytokine storms. While T EM cells use tumor necrosis factor (TNF) superfamily ligands to activate DCs, whether T EM cells prompt other DC-intrinsic changes that influence the innate inflammatory response has never been investigated. We report the surprising discovery that T EM cells trigger double-strand DNA breaks via mitochondrial reactive oxygen species (ROS) production in interacting DCs. Initiation of the DNA damage response in DCs induces activation of a cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS)-independent, non-canonical stimulator of interferon genes (STING)-TNF receptor-associated factor 6 (TRAF6)-nuclear factor κB (NF-κB) signaling axis. Consequently, STING-deficient DCs display reduced NF-κB activation and subsequent defects in transcriptional induction and functional production of interleukin-1β (IL-1β) and IL-6 following their interaction with T EM cells. The discovery of T EM cell-induced innate inflammation through DNA damage and a non-canonical STING-NF-κB pathway presents this pathway as a potential target to alleviate T cell-driven inflammation in autoimmunity and cytokine storms.","journal":"Cell Reports","year":2023,"id":325936,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":569877,"name":"Kathrynne A. Warrick","orcid":"0000-0002-9385-3365","position":1,"is_corresponding":false},{"id":840216,"name":"Andrew VonHandorf","orcid":"0000-0003-2495-2324","position":2,"is_corresponding":false},{"id":1044292,"name":"Charles N. Vallez","orcid":"0000-0001-5720-1098","position":3,"is_corresponding":false},{"id":1044813,"name":"Kiana Kawarizadeh","orcid":null,"position":4,"is_corresponding":false},{"id":638607,"name":"Irene Saha","orcid":"0000-0003-3762-2180","position":5,"is_corresponding":false},{"id":564212,"name":"Omer Donmez","orcid":null,"position":6,"is_corresponding":false},{"id":889053,"name":"Viral G. Jain","orcid":"0000-0002-1897-6461","position":7,"is_corresponding":false},{"id":250976,"name":"Leah C. Kottyan","orcid":"0000-0003-3979-2220","position":8,"is_corresponding":false},{"id":19923,"name":"Matthew T. Weirauch","orcid":"0000-0001-7977-9122","position":9,"is_corresponding":false},{"id":326232,"name":"Chandrashekhar Pasare","orcid":"0000-0002-8142-2488","position":10,"is_corresponding":false},{"id":700419,"name":"Hannah E. Meibers","orcid":"0000-0002-5084-5701","position":0,"is_corresponding":true}],"reference_count":130,"raw_metadata":null,"created_at":"2026-07-19T01:08:28.266998Z","pmid":"37794597","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}