{"doi":"10.1016/j.celrep.2023.113153","title":"Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food","abstract":"The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of allergy-protective Clostridia that contribute to their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole (a ligand for the aryl hydrocarbon receptor [AhR]). Lysates and flagella from a Clostridia consortium induced interleukin-22 (IL-22) secretion from ileal explants. IL-22 production is abrogated in explants from mice in which TLR5 or MyD88 signaling is deficient either globally or conditionally in CD11c + antigen-presenting cells. AhR signaling in RORγt + cells is necessary for the induction of IL-22. Mice deficient in AhR in RORγt + cells exhibit increased intestinal permeability and are more susceptible to an anaphylactic response to food. Our findings implicate TLR5 and AhR signaling in a molecular mechanism by which commensal Clostridia protect against allergic responses to food.","journal":"Cell Reports","year":2023,"id":334094,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":405968,"name":"Robert T. Patry","orcid":null,"position":1,"is_corresponding":false},{"id":682311,"name":"Jack Arnold","orcid":"0000-0002-4840-1327","position":2,"is_corresponding":false},{"id":373986,"name":"Lauren A. Hesser","orcid":"0000-0002-4670-1369","position":3,"is_corresponding":false},{"id":375274,"name":"Evelyn Campbell","orcid":null,"position":4,"is_corresponding":false},{"id":690846,"name":"Edward Ionescu","orcid":"0000-0001-7187-7094","position":5,"is_corresponding":false},{"id":565543,"name":"Mark Mimee","orcid":null,"position":6,"is_corresponding":false},{"id":1062444,"name":"Shan Wang","orcid":"0000-0002-2222-6356","position":7,"is_corresponding":false},{"id":373987,"name":"Cathryn R. Nagler","orcid":"0000-0001-7254-6617","position":8,"is_corresponding":false},{"id":664664,"name":"Andrea M. Kemter","orcid":"0000-0001-7105-7854","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-19T01:09:48.843291Z","pmid":"37742185","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}