{"doi":"10.1016/j.celrep.2023.113151","title":"Neuronal activation of Gαq EGL-30/GNAQ late in life rejuvenates cognition across species","abstract":"signaling pathways are highly conserved between C. elegans and mammals, and murine Gnaq is enriched in hippocampal neurons and declines with age. We found that activation of EGL-30 in aged worms triples memory span, and GNAQ gain of function significantly improved memory in aged mice: GNAQ(gf) in hippocampal neurons of 24-month-old mice (equivalent to 70- to 80-year-old humans) rescued age-related impairments in well-being and memory. Single-nucleus RNA sequencing revealed increased expression of genes regulating synaptic function, axon guidance, and memory in GNAQ-treated mice, and worm orthologs of these genes were required for long-term memory extension in worms. These experiments demonstrate that C. elegans is a powerful model to identify mammalian regulators of memory, leading to the identification of a pathway that improves memory in extremely old mice. To our knowledge, this is the oldest age at which an intervention has improved age-related cognitive decline.","journal":"Cell Reports","year":2023,"id":338804,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9462,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":277061,"name":"Gregor Bieri","orcid":"0000-0003-0737-231X","position":1,"is_corresponding":false},{"id":256013,"name":"Rachel Kaletsky","orcid":"0000-0002-7176-9154","position":2,"is_corresponding":false},{"id":424636,"name":"Jonathan St. Ange","orcid":"0009-0001-2319-8174","position":3,"is_corresponding":false},{"id":1071759,"name":"Laura Remesal","orcid":"0000-0003-0765-6849","position":4,"is_corresponding":false},{"id":1072368,"name":"Karishma J.B. Pratt","orcid":null,"position":5,"is_corresponding":false},{"id":327988,"name":"Shiyi Zhou","orcid":"0000-0002-3824-2588","position":6,"is_corresponding":false},{"id":1071760,"name":"Yifei Weng","orcid":"0009-0003-6229-8631","position":7,"is_corresponding":false},{"id":256015,"name":"Coleen T. Murphy","orcid":"0000-0002-8257-984X","position":8,"is_corresponding":false},{"id":14929,"name":"Saul Villeda","orcid":"0000-0002-2726-9582","position":9,"is_corresponding":false},{"id":1071758,"name":"Morgan E. Stevenson","orcid":"0000-0002-5987-8358","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T01:10:40.496978Z","pmid":"37713310","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}