{"doi":"10.1016/j.celrep.2023.113140","title":"Low dietary fiber intake impairs small intestinal Th17 and intraepithelial T cell development over generations","abstract":"Dietary fiber strongly impacts the microbiota. Here, we show that a low-fiber diet changes the small intestinal (SI) microbiota and impairs SI Th17, TCRαβ + CD8αβ + and TCRαβ + CD8αα + intraepithelial T cell development. We restore T cell development with dietary fiber supplementation, but this defect becomes persistent over generations with constant low-fiber diets. Offspring of low-fiber diet-fed mice have reduced SI T cells even after receiving a fiber-rich diet due to loss of bacteria important for T cell development. In these mice, only a microbiota transplant from a fiber-rich diet-fed mouse and a fiber-rich diet can restore T cell development. Low-fiber diets reduce segmented filamentous bacteria (SFB) abundance, impairing its vertical transmission. SFB colonization and a fiber-rich diet partially restore T cell development. Finally, we observe that low-fiber diet-induced T cell defects render mice more susceptible to Citrobacter rodentium infection. Together, these results demonstrate the importance of fiber to microbiota vertical transmission and host immune system development.","journal":"Cell Reports","year":2023,"id":341681,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.949,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":981004,"name":"Naomi Claudette Rodriguez-Marino","orcid":null,"position":1,"is_corresponding":false},{"id":1078232,"name":"Madelyn D. Yaceczko","orcid":null,"position":2,"is_corresponding":false},{"id":683820,"name":"Dormarie E. Rivera-Rodriguez","orcid":"0000-0002-2091-4104","position":3,"is_corresponding":false},{"id":320518,"name":"Thomas R. Ziegler","orcid":"0000-0001-9329-1481","position":4,"is_corresponding":false},{"id":805469,"name":"Luisa Cervantes‐Barragán","orcid":"0000-0003-1662-7345","position":5,"is_corresponding":false},{"id":738673,"name":"Charlotte J. Royer","orcid":"0000-0002-1107-7092","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:11:08.077724Z","pmid":"37768824","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}