{"doi":"10.1016/j.celrep.2023.113088","title":"VIP interneurons regulate cortical size tuning and visual perception","abstract":"Cortical circuit function is regulated by extensively interconnected, diverse populations of GABAergic interneurons that may play key roles in shaping circuit operation according to behavioral context. A specialized population of interneurons that co-express vasoactive intestinal peptides (VIP-INs) are activated during arousal and innervate other INs and pyramidal neurons (PNs). Although state-dependent modulation of VIP-INs has been extensively studied, their role in regulating sensory processing is less well understood. We examined the impact of VIP-INs in the primary visual cortex of awake behaving mice. Loss of VIP-IN activity alters the behavioral state-dependent modulation of somatostatin-expressing INs (SST-INs) but not PNs. In contrast, reduced VIP-IN activity globally disrupts visual feature selectivity for stimulus size. Moreover, the impact of VIP-INs on perceptual behavior varies with context and is more acute for small than large visual cues. VIP-INs thus contribute to both state-dependent modulation of cortical activity and sensory context-dependent perceptual performance.","journal":"Cell Reports","year":2023,"id":321483,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1034092,"name":"Jenna Salameh","orcid":null,"position":1,"is_corresponding":false},{"id":805820,"name":"Christopher Alba","orcid":"0000-0001-8692-7656","position":2,"is_corresponding":false},{"id":1033586,"name":"Hannah Selwyn","orcid":"0000-0003-1570-9576","position":3,"is_corresponding":false},{"id":1033587,"name":"Clayton Barnes","orcid":"0000-0003-2471-6268","position":4,"is_corresponding":false},{"id":553475,"name":"Sweyta Lohani","orcid":"0000-0001-8209-5303","position":5,"is_corresponding":false},{"id":553478,"name":"Jessica A. Cardin","orcid":"0000-0002-8209-5466","position":6,"is_corresponding":false},{"id":1033585,"name":"Katie Ferguson","orcid":"0000-0003-0534-0867","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-19T01:07:32.611759Z","pmid":"37682710","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}