{"doi":"10.1016/j.celrep.2023.112993","title":"Transplantation elicits a clonally diverse CD8+ T cell response that is comprised of potent CD43+ effectors","abstract":"CD8 + T cells mediate acute rejection of allografts, which threatens the long-term survival of transplanted organs. Using MHC class I tetramers, we find that allogeneic CD8 + T cells are present at an elevated naive precursor frequency relative to other epitopes, only modestly increase in number after grafting, and maintain high T cell receptor diversity throughout the immune response. While antigen-specific effector CD8 + T cells poorly express the canonical effector marker KLRG-1, expression of the activated glycoform of CD43 defines potent effectors after transplantation. Activated CD43 + effector T cells maintain high expression of the coreceptor induced T cell costimulator (ICOS) in the presence of CTLA-4 immunoglobulin (Ig), and dual CTLA-4 Ig/anti-ICOS treatment prolongs graft survival. These data demonstrate that graft-specific CD8 + T cells have a distinct response profile relative to anti-pathogen CD8 + T cells and that CD43 and ICOS are critical surface receptors that define potent effector CD8 + T cell populations that form after transplantation.","journal":"Cell Reports","year":2023,"id":348286,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9545,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":997211,"name":"Melissa A. Kallarakal","orcid":"0009-0000-9948-3871","position":1,"is_corresponding":false},{"id":808762,"name":"Sahana Jayaraman","orcid":"0000-0003-3413-2530","position":2,"is_corresponding":false},{"id":997748,"name":"Francis I. Ibukun","orcid":null,"position":3,"is_corresponding":false},{"id":505684,"name":"Katherine P. Tong","orcid":null,"position":4,"is_corresponding":false},{"id":1003428,"name":"Linda D. Orzolek","orcid":null,"position":5,"is_corresponding":false},{"id":108428,"name":"H. Benjamin Larman","orcid":"0000-0001-7863-196X","position":6,"is_corresponding":false},{"id":504860,"name":"Scott M. Krummey","orcid":"0000-0002-7504-9162","position":7,"is_corresponding":false},{"id":997212,"name":"G. Cohen","orcid":"0000-0001-6652-4403","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T01:12:06.040073Z","pmid":"37590141","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}