{"doi":"10.1016/j.celrep.2023.112990","title":"Enhancing autophagy in CD11c+ antigen-presenting cells as a therapeutic strategy for acute respiratory distress syndrome","abstract":"Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe clinical disorders that mainly develop from viral respiratory infections, sepsis, and chest injury. Antigen-presenting cells play a pivotal role in propagating uncontrolled inflammation and injury through the excess secretion of pro-inflammatory cytokines and recruitment of immune cells. Autophagy, a homeostatic process that involves the degradation of cellular components, is involved in many processes including lung inflammation. Here, we use a polyinosinic-polycytidylic acid (poly(I:C))-induced lung injury mouse model to mimic viral-induced ALI/ARDS and show that disruption of autophagy in macrophages exacerbates lung inflammation and injury, whereas autophagy induction attenuates this process. Therefore, induction of autophagy in macrophages can be a promising therapeutic strategy in ALI/ARDS.","journal":"Cell Reports","year":2023,"id":344837,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":252066,"name":"Doumet Georges Helou","orcid":"0000-0002-5835-9214","position":1,"is_corresponding":false},{"id":1083740,"name":"Meng Li","orcid":"0009-0007-6919-3858","position":2,"is_corresponding":false},{"id":241528,"name":"Benjamin P. Hurrell","orcid":"0000-0001-7753-2927","position":3,"is_corresponding":false},{"id":253285,"name":"Emily Howard","orcid":null,"position":4,"is_corresponding":false},{"id":241527,"name":"Pedram Shafiei-Jahani","orcid":"0000-0003-1768-0770","position":5,"is_corresponding":false},{"id":253288,"name":"Pejman Soroosh","orcid":null,"position":6,"is_corresponding":false},{"id":710162,"name":"Jing‐hsiung James Ou","orcid":"0000-0002-8274-5705","position":7,"is_corresponding":false},{"id":241767,"name":"Babak Razani","orcid":"0000-0002-7172-9240","position":8,"is_corresponding":false},{"id":337039,"name":"Virender K. Rehan","orcid":"0000-0002-8948-8967","position":9,"is_corresponding":false},{"id":241529,"name":"Omid Akbari","orcid":"0000-0002-4359-9725","position":10,"is_corresponding":false},{"id":660358,"name":"Christine Quach","orcid":"0000-0003-4802-8013","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T01:11:35.133818Z","pmid":"37590140","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}