{"doi":"10.1016/j.celrep.2023.112958","title":"Epstein-Barr virus evades restrictive host chromatin closure by subverting B cell activation and germinal center regulatory loci","abstract":"Chromatin accessibility fundamentally governs gene expression and biological response programs that can be manipulated by pathogens. Here we capture dynamic chromatin landscapes of individual B cells during Epstein-Barr virus (EBV) infection. EBV + cells that exhibit arrest via antiviral sensing and proliferation-linked DNA damage experience global accessibility reduction. Proliferative EBV + cells develop expression-linked architectures and motif accessibility profiles resembling in vivo germinal center (GC) phenotypes. Remarkably, EBV elicits dark zone (DZ), light zone (LZ), and post-GC B cell chromatin features despite BCL6 downregulation. Integration of single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq), single-cell RNA sequencing (scRNA-seq), and chromatin immunoprecipitation sequencing (ChIP-seq) data enables genome-wide cis -regulatory predictions implicating EBV nuclear antigens (EBNAs) in phenotype-specific control of GC B cell activation, survival, and immune evasion. Knockouts validate bioinformatically identified regulators ( MEF2C and NFE2L2 ) of EBV-induced GC phenotypes and EBNA-associated loci that regulate gene expression ( CD274 /PD-L1). These data and methods can inform high-resolution investigations of EBV-host interactions, B cell fates, and virus-mediated lymphomagenesis.","journal":"Cell Reports","year":2023,"id":328367,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9538,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":860217,"name":"Nicolás M. Reinoso-Vizcaíno","orcid":"0000-0002-9769-3768","position":1,"is_corresponding":false},{"id":571587,"name":"Joanne Dai","orcid":"0000-0002-9879-4704","position":2,"is_corresponding":false},{"id":991845,"name":"Ashley P. Barry","orcid":"0000-0002-2158-1516","position":3,"is_corresponding":false},{"id":432169,"name":"Cliburn Chan","orcid":"0000-0001-5901-6806","position":4,"is_corresponding":false},{"id":395715,"name":"Micah A. Luftig","orcid":"0000-0002-2964-1907","position":5,"is_corresponding":false},{"id":577327,"name":"Elliott D. SoRelle","orcid":"0000-0002-3362-1028","position":0,"is_corresponding":true}],"reference_count":136,"raw_metadata":null,"created_at":"2026-07-19T01:08:52.196069Z","pmid":"37561629","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}