{"doi":"10.1016/j.celrep.2023.112951","title":"A binary module for microbiota-mediated regulation of γδ17 cells, hallmarked by microbiota-driven expression of programmed cell death protein 1","abstract":"Little is known about how microbiota regulate innate-like γδ T cells or how these restrict their effector functions within mucosal barriers, where microbiota provide chronic stimulation. Here, we show that microbiota-mediated regulation of γδ17 cells is binary, where microbiota instruct in situ interleukin-17 (IL-17) production and concomitant expression of the inhibitory receptor programmed cell death protein 1 (PD-1). Microbiota-driven expression of PD-1 and IL-17 and preferential adoption of a PD-1 high phenotype are conserved for γδ17 cells across multiple mucosal barriers. Importantly, microbiota-driven PD-1 inhibits in situ IL-17 production by mucosa-resident γδ17 effectors, linking microbiota to their simultaneous activation and suppression. We further show the dynamic nature of this microbiota-driven module and define an inflammation-associated activation state for γδ17 cells marked by augmented PD-1, IL-17, and lipid uptake, thus linking the microbiota to dynamic subset-specific activation and metabolic remodeling to support γδ17 effector functions in a microbiota-dense tissue environment.","journal":"Cell Reports","year":2023,"id":382280,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1148467,"name":"Yue Xue","orcid":"0009-0004-2141-2044","position":1,"is_corresponding":false},{"id":367892,"name":"Mark L. Jewell","orcid":null,"position":2,"is_corresponding":false},{"id":244650,"name":"Chin Yee Tan","orcid":"0000-0003-1104-6082","position":3,"is_corresponding":false},{"id":1148811,"name":"Barbara S. Theriot","orcid":null,"position":4,"is_corresponding":false},{"id":511470,"name":"Nupur Aggarwal","orcid":"0000-0002-7992-0023","position":5,"is_corresponding":false},{"id":347853,"name":"Jacob Dockterman","orcid":"0000-0002-9630-7490","position":6,"is_corresponding":false},{"id":417292,"name":"Yang‐Ding Lin","orcid":"0000-0003-2975-8272","position":7,"is_corresponding":false},{"id":910194,"name":"Erin A. Schroeder","orcid":"0000-0003-1891-8015","position":8,"is_corresponding":false},{"id":781808,"name":"Donghai Wang","orcid":"0000-0003-4273-6115","position":9,"is_corresponding":false},{"id":375975,"name":"Na Xiong","orcid":"0000-0003-4405-6818","position":10,"is_corresponding":false},{"id":249863,"name":"Jörn Coers","orcid":"0000-0001-8707-4608","position":11,"is_corresponding":false},{"id":249988,"name":"Mari L. Shinohara","orcid":"0000-0002-6808-9844","position":12,"is_corresponding":false},{"id":244663,"name":"Neeraj K. Surana","orcid":"0000-0002-9544-2551","position":13,"is_corresponding":false},{"id":366378,"name":"Gianna Hammer","orcid":"0000-0001-6959-858X","position":14,"is_corresponding":false},{"id":366373,"name":"Hsin-I Huang","orcid":"0000-0001-9106-9449","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:17:17.113710Z","pmid":"37556321","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}