{"doi":"10.1016/j.celrep.2023.112909","title":"All-optical recreation of naturalistic neural activity with a multifunctional transgenic reporter mouse","abstract":"Determining which features of the neural code drive behavior requires the ability to simultaneously read out and write in neural activity patterns with high precision across many neurons. All-optical systems that combine two-photon calcium imaging and targeted photostimulation enable the activation of specific, functionally defined groups of neurons. However, these techniques are unable to test how patterns of activity across a population contribute to computation because of an inability to both read and write cell-specific firing rates. To overcome this challenge, we make two advances: first, we introduce a genetic line of mice for Cre-dependent co-expression of a calcium indicator and a potent soma-targeted microbial opsin. Second, using this line, we develop a method for read-out and write-in of precise population vectors of neural activity by calibrating the photostimulation to each cell. These advances offer a powerful and convenient platform for investigating the neural codes of computation and behavior.","journal":"Cell Reports","year":2023,"id":327353,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9485,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":545468,"name":"Masato Sadahiro","orcid":"0000-0003-4164-565X","position":1,"is_corresponding":false},{"id":983471,"name":"William D. Hendricks","orcid":"0000-0003-2841-577X","position":2,"is_corresponding":false},{"id":984338,"name":"Marta Gajowa","orcid":"0000-0002-6399-6883","position":3,"is_corresponding":false},{"id":1047479,"name":"Karthika Gopakumar","orcid":"0000-0003-3574-642X","position":4,"is_corresponding":false},{"id":618359,"name":"Daniel Quintana","orcid":"0000-0003-2876-0004","position":5,"is_corresponding":false},{"id":12975,"name":"Bosiljka Tasic","orcid":"0000-0002-6861-4506","position":6,"is_corresponding":false},{"id":38330,"name":"Tanya L. Daigle","orcid":"0000-0001-9700-8452","position":7,"is_corresponding":false},{"id":23581,"name":"Hongkui Zeng","orcid":"0000-0002-0326-5878","position":8,"is_corresponding":false},{"id":676808,"name":"Ian Antón Oldenburg","orcid":"0000-0002-7356-104X","position":9,"is_corresponding":false},{"id":542596,"name":"Hillel Adesnik","orcid":"0000-0002-3796-8643","position":10,"is_corresponding":false},{"id":983472,"name":"Hayley A. Bounds","orcid":"0000-0002-2774-6596","position":0,"is_corresponding":true}],"reference_count":114,"raw_metadata":null,"created_at":"2026-07-19T01:08:42.846627Z","pmid":"37542722","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}