{"doi":"10.1016/j.celrep.2023.112839","title":"Lung injury induces a polarized immune response by self-antigen-specific CD4+ Foxp3+ regulatory T cells","abstract":"Self-antigen-specific T cells are prevalent in the mature adaptive immune system but are regulated through multiple mechanisms of tolerance. However, inflammatory conditions such as tissue injury may allow these T cells to break tolerance and trigger autoimmunity. To understand how the T cell repertoire responds to the presentation of self-antigen under highly stimulatory conditions, we use peptide:major histocompatibility complex (MHC) class II tetramers to track the behavior of endogenous CD4 + T cells with specificity to a lung-expressed self-antigen in mouse models of immune-mediated lung injury. Acute injury results in the exclusive expansion of CD4 + regulatory T cells (Tregs) that is dependent on self-antigen recognition and interleukin-2 (IL-2). Conversely, conventional CD4 + T cells of the same self-antigen specificity remain unresponsive even following Treg ablation. Thus, the self-antigen-specific CD4 + T cell repertoire is poised to serve a regulatory function during acute tissue damage to limit further damage and the possibility of autoimmunity.","journal":"Cell Reports","year":2023,"id":333984,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":409385,"name":"Sneha Ratnapriya","orcid":"0000-0003-0466-4771","position":1,"is_corresponding":false},{"id":1061899,"name":"Creel Ng Cashin","orcid":"0000-0002-6017-7452","position":2,"is_corresponding":false},{"id":1061900,"name":"Lucy F. Kuhn","orcid":"0000-0002-2058-0335","position":3,"is_corresponding":false},{"id":268518,"name":"Rod A. Rahimi","orcid":"0000-0002-7929-2899","position":4,"is_corresponding":false},{"id":254347,"name":"Robert M. Anthony","orcid":"0000-0002-7283-7825","position":5,"is_corresponding":false},{"id":281386,"name":"James J. Moon","orcid":"0000-0001-8246-931X","position":6,"is_corresponding":false},{"id":1028497,"name":"Daniel S. Shin","orcid":"0000-0001-5873-1920","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T01:09:44.297718Z","pmid":"37471223","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}