{"doi":"10.1016/j.celrep.2023.112789","title":"AgRP neurons are not indispensable for body weight maintenance in adult mice","abstract":"In addition to their role in promoting feeding and obesity development, hypothalamic arcuate agouti-related protein/neuropeptide Y (AgRP/NPY) neurons are widely perceived to be indispensable for maintaining normal feeding and body weight in adults, and consistently, acute inhibition of AgRP neurons is known to reduce short-term food intake. Here, we adopted complementary methods to achieve nearly complete ablation of arcuate AgRP/NPY neurons in adult mice and report that lesioning arcuate AgRP/NPY neurons in adult mice causes no apparent alterations in ad libitum feeding or body weight. Consistent with previous studies, loss of AgRP/NPY neurons blunts fasting refeeding. Thus, our studies show that AgRP/NPY neurons are not required for maintaining ad libitum feeding or body weight homeostasis in adult mice.","journal":"Cell Reports","year":2023,"id":319636,"datarank":1.1512620528652362,"base_score":4.007333185232471,"endowment":4.007333185232471,"self_citation_contribution":0.6010999777848708,"citation_network_contribution":0.5501620750803655,"self_endowment_contribution":0.6010999777848708,"citer_contribution":0.5501620750803655,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":50,"citers_with_citation_signal":32,"citers_with_endowment":32,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9508,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":713381,"name":"Jing Chen","orcid":"0000-0003-1894-335X","position":1,"is_corresponding":false},{"id":818017,"name":"Joshua Ortiz‐Guzman","orcid":"0000-0002-7000-394X","position":2,"is_corresponding":false},{"id":237567,"name":"Jessica Huang","orcid":"0000-0001-8674-5924","position":3,"is_corresponding":false},{"id":345562,"name":"Benjamin R. Arenkiel","orcid":"0000-0001-9047-2420","position":4,"is_corresponding":false},{"id":1029249,"name":"Yuchen Wang","orcid":"0000-0002-5862-8322","position":5,"is_corresponding":false},{"id":527193,"name":"Yan Zhang","orcid":"0009-0006-0145-302X","position":6,"is_corresponding":false},{"id":968565,"name":"Yuyan Shi","orcid":"0000-0001-9293-0659","position":7,"is_corresponding":false},{"id":296409,"name":"Qingchun Tong","orcid":"0000-0002-4561-2540","position":8,"is_corresponding":false},{"id":851633,"name":"Cheng Zhan","orcid":"0000-0001-9397-0871","position":9,"is_corresponding":false},{"id":702016,"name":"Jing Cai","orcid":"0000-0001-8448-8151","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:07:17.361058Z","pmid":"37422762","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}