{"doi":"10.1016/j.celrep.2023.112785","title":"Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice","abstract":"Peripheral inflammation has been linked to various neurodegenerative disorders, including Alzheimer's disease (AD). Here we perform bulk, single-cell, and spatial transcriptomics in APP/PS1 mice intranasally exposed to Staphylococcus aureus to determine how low-grade peripheral infection affects brain transcriptomics and AD-like pathology. Chronic exposure led to increased amyloid plaque burden and plaque-associated microglia, significantly affecting the transcription of brain barrier-associated cells, which resulted in barrier leakage. We reveal cell-type- and spatial-specific transcriptional changes related to brain barrier function and neuroinflammation during the acute infection. Both acute and chronic exposure led to brain macrophage-associated responses and detrimental effects in neuronal transcriptomics. Finally, we identify unique transcriptional responses at the amyloid plaque niches following acute infection characterized by higher disease-associated microglia gene expression and a larger effect on astrocytic or macrophage-associated genes, which could facilitate amyloid and related pathologies. Our findings provide important insights into the mechanisms linking peripheral inflammation to AD pathology.","journal":"Cell Reports","year":2023,"id":326213,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9601,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1045095,"name":"Carolina Saibro Girardi","orcid":"0000-0002-1685-011X","position":1,"is_corresponding":false},{"id":308859,"name":"Nicholas F. Fitz","orcid":"0000-0001-6938-6536","position":2,"is_corresponding":false},{"id":1045773,"name":"Mikayla Ranae McGuire","orcid":null,"position":3,"is_corresponding":false},{"id":1045774,"name":"Mary Ann Ostach","orcid":null,"position":4,"is_corresponding":false},{"id":1045096,"name":"A. N. M. Mamun-Or-Rashid","orcid":"0000-0002-0155-4676","position":5,"is_corresponding":false},{"id":308864,"name":"Iliya Lefterov","orcid":"0000-0002-0249-0280","position":6,"is_corresponding":false},{"id":308865,"name":"Radosveta Koldamova","orcid":"0000-0002-6761-0984","position":7,"is_corresponding":false},{"id":308862,"name":"Yi Lü","orcid":"0000-0002-1060-6925","position":0,"is_corresponding":true}],"reference_count":83,"raw_metadata":null,"created_at":"2026-07-19T01:08:33.106703Z","pmid":"37436901","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}