{"doi":"10.1016/j.celrep.2023.112783","title":"Cortical regulation of neurogenesis and cell proliferation in the ventral subventricular zone","abstract":"Neurogenesis and differentiation of neural stem cells (NSCs) are controlled by cell-intrinsic molecular pathways that interact with extrinsic signaling cues. In this study, we identify a circuit that regulates neurogenesis and cell proliferation in the lateral ventricle-subventricular zone (LV-SVZ). Our results demonstrate that direct glutamatergic projections from the anterior cingulate cortex (ACC), as well as inhibitory projections from calretinin + local interneurons, modulate the activity of cholinergic neurons in the subependymal zone (subep-ChAT + ). Furthermore, in vivo optogenetic stimulation and inhibition of the ACC-subep-ChAT + circuit are sufficient to control neurogenesis in the ventral SVZ. Both subep-ChAT + and local calretinin + neurons play critical roles in regulating ventral SVZ neurogenesis and LV-SVZ cell proliferation.","journal":"Cell Reports","year":2023,"id":344651,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9469,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1083488,"name":"Rehan Khan","orcid":"0000-0002-0741-1238","position":1,"is_corresponding":false},{"id":710804,"name":"Chay T. Kuo","orcid":null,"position":2,"is_corresponding":false},{"id":351424,"name":"Henry H. Yin","orcid":"0000-0003-1546-6850","position":3,"is_corresponding":false},{"id":864665,"name":"Moawiah M. Naffaa","orcid":"0000-0003-0451-5901","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T01:11:35.133818Z","pmid":"37422764","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}