{"doi":"10.1016/j.celrep.2023.112780","title":"Tracking B cell responses to the SARS-CoV-2 mRNA-1273 vaccine","abstract":"Protective immunity following vaccination is sustained by long-lived antibody-secreting cells and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 vaccination are evaluated longitudinally by multimodal single-cell analysis in three infection-naïve individuals. Integrated surface protein, transcriptomics, and B cell receptor (BCR) repertoire analysis of sorted plasmablasts and spike + (S-2P + ) and S-2P − B cells reveal clonal expansion and accumulating mutations among S-2P + cells. These cells are enriched in a cluster of immunoglobulin G-expressing MBCs and evolve along a bifurcated trajectory rooted in CXCR3 + MBCs. One branch leads to CD11c + atypical MBCs while the other develops from CD71 + activated precursors to resting MBCs, the dominant population at month 6. Among 12 evolving S-2P + clones, several are populated with plasmablasts at early timepoints as well as CD71 + activated and resting MBCs at later timepoints, and display intra- and/or inter-cohort BCR convergence. These relationships suggest a coordinated and predictable evolution of SARS-CoV-2 vaccine-generated MBCs.","journal":"Cell Reports","year":2023,"id":326946,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":255166,"name":"Kenneth B. Hoehn","orcid":"0000-0003-0411-4307","position":1,"is_corresponding":false},{"id":812619,"name":"Xiaozhen Zhang","orcid":"0000-0003-3567-8789","position":2,"is_corresponding":false},{"id":248214,"name":"Lela Kardava","orcid":null,"position":3,"is_corresponding":false},{"id":497627,"name":"Connor D. Smith","orcid":"0000-0002-6858-0799","position":4,"is_corresponding":false},{"id":857368,"name":"Omar El Merhebi","orcid":"0000-0001-5895-5078","position":5,"is_corresponding":false},{"id":748490,"name":"Clarisa M. Buckner","orcid":"0000-0002-8178-8076","position":6,"is_corresponding":false},{"id":812617,"name":"Krittin Trihemasava","orcid":"0000-0002-4017-1256","position":7,"is_corresponding":false},{"id":857369,"name":"Wei Wang","orcid":"0000-0002-9374-2374","position":8,"is_corresponding":false},{"id":471708,"name":"Catherine Seamon","orcid":"0000-0002-9436-9903","position":9,"is_corresponding":false},{"id":228411,"name":"Vicky Chen","orcid":"0000-0003-4595-154X","position":10,"is_corresponding":false},{"id":956701,"name":"Paul Schaughency","orcid":"0000-0002-3358-2102","position":11,"is_corresponding":false},{"id":248215,"name":"Foo Cheung","orcid":null,"position":12,"is_corresponding":false},{"id":245096,"name":"Andrew J. Martins","orcid":"0000-0002-1832-1924","position":13,"is_corresponding":false},{"id":450568,"name":"Chi-I Chiang","orcid":null,"position":14,"is_corresponding":false},{"id":449696,"name":"Yuxing Li","orcid":"0000-0001-9785-2960","position":15,"is_corresponding":false},{"id":78353,"name":"John S. Tsang","orcid":"0000-0003-3186-3047","position":16,"is_corresponding":false},{"id":228710,"name":"Tae‐Wook Chun","orcid":"0000-0001-5153-7340","position":17,"is_corresponding":false},{"id":6493,"name":"Steven H. Kleinstein","orcid":"0000-0003-4957-1544","position":18,"is_corresponding":false},{"id":245106,"name":"Susan Moir","orcid":"0000-0002-0163-6911","position":19,"is_corresponding":false},{"id":770122,"name":"Felipe Lopes de Assis","orcid":"0000-0003-4342-8632","position":0,"is_corresponding":true}],"reference_count":93,"raw_metadata":null,"created_at":"2026-07-19T01:08:37.840107Z","pmid":"37440409","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}