{"doi":"10.1016/j.celrep.2023.112755","title":"HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide","abstract":"Elicitation of antibodies that neutralize the tier-2 neutralization-resistant isolates that typify HIV-1 transmission has been a long-sought goal. Success with prefusion-stabilized envelope trimers eliciting autologous neutralizing antibodies has been reported in multiple vaccine-test species, though not in humans. To investigate elicitation of HIV-1 neutralizing antibodies in humans, here, we analyze B cells from a phase I clinical trial of the \"DS-SOSIP\"-stabilized envelope trimer from strain BG505, identifying two antibodies, N751-2C06.01 and N751-2C09.01 (named for donor-lineage.clone), that neutralize the autologous tier-2 strain, BG505. Though derived from distinct lineages, these antibodies form a reproducible antibody class that targets the HIV-1 fusion peptide. Both antibodies are highly strain specific, which we attribute to their partial recognition of a BG505-specific glycan hole and to their binding requirements for a few BG505-specific residues. Prefusion-stabilized envelope trimers can thus elicit autologous tier-2 neutralizing antibodies in humans, with initially identified neutralizing antibodies recognizing the fusion-peptide site of vulnerability.","journal":"Cell Reports","year":2023,"id":338586,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1071458,"name":"Flavio Matassoli","orcid":"0009-0000-5559-8781","position":1,"is_corresponding":false},{"id":229158,"name":"Baoshan Zhang","orcid":"0000-0002-0165-1513","position":2,"is_corresponding":false},{"id":622891,"name":"Tracy Liu","orcid":"0000-0003-0671-8390","position":3,"is_corresponding":false},{"id":390894,"name":"Chen‐Hsiang Shen","orcid":"0000-0002-9560-3992","position":4,"is_corresponding":false},{"id":621095,"name":"Tatsiana Bylund","orcid":"0000-0002-2065-2773","position":5,"is_corresponding":false},{"id":266258,"name":"Timothy S. Johnston","orcid":"0000-0001-9246-6155","position":6,"is_corresponding":false},{"id":619541,"name":"Amy R. Henry","orcid":null,"position":7,"is_corresponding":false},{"id":229156,"name":"I‐Ting Teng","orcid":"0000-0002-4704-7100","position":8,"is_corresponding":false},{"id":663803,"name":"Prabhanshu Tripathi","orcid":"0000-0003-1282-2848","position":9,"is_corresponding":false},{"id":1072150,"name":"Jordan E. Becker","orcid":null,"position":10,"is_corresponding":false},{"id":324810,"name":"Anita Changela","orcid":null,"position":11,"is_corresponding":false},{"id":1072151,"name":"Ridhi Chaudhary","orcid":null,"position":12,"is_corresponding":false},{"id":121105,"name":"Cheng Cheng","orcid":"0000-0002-9895-6240","position":13,"is_corresponding":false},{"id":622895,"name":"Martin R. 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