{"doi":"10.1016/j.celrep.2023.112634","title":"Identification of aryl hydrocarbon receptor as a barrier to HIV-1 infection and outgrowth in CD4+ T cells","abstract":"The aryl hydrocarbon receptor (AhR) regulates Th17-polarized CD4 + T cell functions, but its role in HIV-1 replication/outgrowth remains unknown. Genetic (CRISPR-Cas9) and pharmacological inhibition reveal AhR as a barrier to HIV-1 replication in T cell receptor (TCR)-activated CD4 + T cells in vitro . In single-round vesicular stomatitis virus (VSV)-G-pseudotyped HIV-1 infection, AhR blockade increases the efficacy of early/late reverse transcription and subsequently facilitated integration/translation. Moreover, AhR blockade boosts viral outgrowth in CD4 + T cells of people living with HIV-1 (PLWH) receiving antiretroviral therapy (ART). Finally, RNA sequencing reveals genes/pathways downregulated by AhR blockade in CD4 + T cells of ART-treated PLWH, including HIV-1 interactors and gut-homing molecules with AhR-responsive elements in their promoters. Among them, HIC1, a repressor of Tat-mediated HIV-1 transcription and a tissue-residency master regulator, is identified by chromatin immunoprecipitation as a direct AhR target. Thus, AhR governs a T cell transcriptional program controlling viral replication/outgrowth and tissue residency/recirculation, supporting the use of AhR inhibitors in \"shock and kill\" HIV-1 remission/cure strategies.","journal":"Cell Reports","year":2023,"id":337340,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9603,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1068699,"name":"Yuwei Zhang","orcid":"0000-0001-8927-3184","position":1,"is_corresponding":false},{"id":1069192,"name":"Christ-Dominique Ngassaki-Yoka","orcid":null,"position":2,"is_corresponding":false},{"id":1069193,"name":"Antoine Dutilleul","orcid":null,"position":3,"is_corresponding":false},{"id":1069194,"name":"Soumia Khalfi","orcid":null,"position":4,"is_corresponding":false},{"id":1068700,"name":"Olivier Hernalsteens","orcid":"0000-0002-4118-8068","position":5,"is_corresponding":false},{"id":343164,"name":"Tomas Raul Wiche Salinas","orcid":null,"position":6,"is_corresponding":false},{"id":1068701,"name":"Jonathan Dias","orcid":"0000-0002-7842-0115","position":7,"is_corresponding":false},{"id":1068702,"name":"Huicheng Chen","orcid":"0000-0001-9156-3391","position":8,"is_corresponding":false},{"id":1069195,"name":"Yasmine Smail","orcid":null,"position":9,"is_corresponding":false},{"id":487405,"name":"Jean-Philippe Goulet","orcid":null,"position":10,"is_corresponding":false},{"id":585940,"name":"Brendan Bell","orcid":"0000-0001-6885-940X","position":11,"is_corresponding":false},{"id":233493,"name":"Jean‐Pierre Routy","orcid":"0000-0001-9897-7589","position":12,"is_corresponding":false},{"id":457360,"name":"Carine Van Lint","orcid":"0000-0002-2219-2862","position":13,"is_corresponding":false},{"id":18101,"name":"Petronela Ancuța","orcid":"0000-0003-1922-5640","position":14,"is_corresponding":false},{"id":846329,"name":"Debashree Chatterjee","orcid":"0000-0003-0276-9262","position":0,"is_corresponding":true}],"reference_count":89,"raw_metadata":null,"created_at":"2026-07-19T01:10:26.690308Z","pmid":"37310858","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}