{"doi":"10.1016/j.celrep.2023.112628","title":"VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome","abstract":"Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by loss-of-function variants in SCN1A , which encodes the voltage-gated sodium channel subunit Nav1.1. We recently showed that neocortical vasoactive intestinal peptide interneurons (VIP-INs) express Nav1.1 and are hypoexcitable in DS ( Scn1a +/− ) mice. Here, we investigate VIP-IN function at the circuit and behavioral level by performing in vivo 2-photon calcium imaging in awake wild-type (WT) and Scn1a +/− mice. VIP-IN and pyramidal neuron activation during behavioral transition from quiet wakefulness to active running is diminished in Scn1a +/− mice, and optogenetic activation of VIP-INs restores pyramidal neuron activity to WT levels during locomotion. VIP-IN selective Scn1a deletion reproduces core autism-spectrum-disorder-related behaviors in addition to cellular- and circuit-level deficits in VIP-IN function, but without epilepsy, sudden death, or avoidance behaviors seen in the global model. Hence, VIP-INs are impaired in vivo , which may underlie non-seizure cognitive and behavioral comorbidities in DS.","journal":"Cell Reports","year":2023,"id":323376,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9571,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1038168,"name":"Sophie R Liebergall","orcid":"0000-0001-6744-4835","position":1,"is_corresponding":false},{"id":372785,"name":"Evan Jiang","orcid":null,"position":2,"is_corresponding":false},{"id":284608,"name":"Ala Somarowthu","orcid":"0000-0001-8109-3816","position":3,"is_corresponding":false},{"id":227207,"name":"Ethan M. Goldberg","orcid":"0000-0002-7404-735X","position":4,"is_corresponding":false},{"id":284609,"name":"Kevin M. Goff","orcid":"0000-0001-5862-0219","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T01:07:52.377944Z","pmid":"37310860","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}