{"doi":"10.1016/j.celrep.2023.112544","title":"Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma","abstract":"Maternal RNAs are stored from minutes to decades in oocytes throughout meiosis I arrest in a transcriptionally quiescent state. Recent reports, however, propose a role for nascent transcription in arrested oocytes. Whether arrested oocytes launch nascent transcription in response to environmental or hormonal signals while maintaining the meiosis I arrest remains undetermined. We test this by integrating single-cell RNA sequencing, RNA velocity, and RNA fluorescence in situ hybridization on C. elegans meiosis I arrested oocytes. We identify transcripts that increase as the arrested meiosis I oocyte ages, but rule out extracellular signaling through ERK MAPK and nascent transcription as a mechanism for this increase. We report transcript acquisition from neighboring somatic cells as a mechanism of transcript increase during meiosis I arrest. These analyses provide a deeper view at single-cell resolution of the RNA landscape of a meiosis I arrested oocyte and as it prepares for oocyte maturation and fertilization.","journal":"Cell Reports","year":2023,"id":347828,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":824176,"name":"Peisen Zhao","orcid":"0000-0002-3787-193X","position":1,"is_corresponding":false},{"id":573762,"name":"Jacob Seemann","orcid":"0000-0002-5113-9788","position":2,"is_corresponding":false},{"id":506952,"name":"Shin-Yu Chen","orcid":"0000-0002-8174-7741","position":3,"is_corresponding":false},{"id":561711,"name":"Sudip Mondal","orcid":"0000-0002-5387-0064","position":4,"is_corresponding":false},{"id":382820,"name":"Adela Ben‐Yakar","orcid":"0000-0003-3468-6146","position":5,"is_corresponding":false},{"id":506953,"name":"Swathi Arur","orcid":"0000-0002-6941-2711","position":6,"is_corresponding":false},{"id":400648,"name":"Kenneth A. Trimmer","orcid":"0000-0003-2161-4645","position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:12:01.859977Z","pmid":"37227820","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}