{"doi":"10.1016/j.celrep.2023.112512","title":"STAT3 signaling in B cells controls germinal center zone organization and recycling","abstract":"Germinal centers (GCs), sites of antibody affinity maturation, are organized into dark (DZ) and light (LZ) zones. Here, we show a B cell-intrinsic role for signal transducer and activator of transcription 3 (STAT3) in GC DZ and LZ organization. Altered zonal organization of STAT3-deficient GCs dampens development of long-lived plasma cells (LL-PCs) but increases memory B cells (MBCs). In an abundant antigenic environment, achieved here by prime-boost immunization, STAT3 is not required for GC initiation, maintenance, or proliferation but is important for sustaining GC zonal organization by regulating GC B cell recycling. Th cell-derived signals drive STAT3 tyrosine 705 and serine 727 phosphorylation in LZ B cells, regulating their recycling into the DZ. RNA sequencing (RNA-seq) and chromatin immunoprecipitation sequencing (ChIP-seq) analyses identified STAT3 regulated genes that are critical for LZ cell recycling and transiting through DZ proliferation and differentiation phases. Thus, STAT3 signaling in B cells controls GC zone organization and recycling, and GC egress of PCs, but negatively regulates MBC output.","journal":"Cell Reports","year":2023,"id":332016,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":413546,"name":"Sathi Babu Chodisetti","orcid":"0000-0001-7473-9420","position":1,"is_corresponding":false},{"id":286116,"name":"Nathaniel Wright","orcid":"0000-0001-7006-4040","position":2,"is_corresponding":false},{"id":788943,"name":"Kristen N Bricker","orcid":"0000-0001-8963-9780","position":3,"is_corresponding":false},{"id":413547,"name":"Phillip P. Domeier","orcid":"0000-0002-9937-8251","position":4,"is_corresponding":false},{"id":248228,"name":"Mark Maienschein‐Cline","orcid":null,"position":5,"is_corresponding":false},{"id":108194,"name":"Aaron M. Rosenfeld","orcid":"0000-0002-2266-0355","position":6,"is_corresponding":false},{"id":816265,"name":"Sara Luckenbill","orcid":"0000-0002-8035-2246","position":7,"is_corresponding":false},{"id":1057533,"name":"Julia L. Weber","orcid":"0000-0003-1121-0460","position":8,"is_corresponding":false},{"id":413548,"name":"Nicholas Choi","orcid":"0000-0003-4801-4973","position":9,"is_corresponding":false},{"id":244597,"name":"Eline T. Luning Prak","orcid":"0000-0002-9478-9211","position":10,"is_corresponding":false},{"id":262499,"name":"Malay Mandal","orcid":"0000-0002-0451-3896","position":11,"is_corresponding":false},{"id":262502,"name":"Marcus R. Clark","orcid":"0000-0003-4747-0387","position":12,"is_corresponding":false},{"id":413549,"name":"Ziaur S. M. Rahman","orcid":"0000-0001-8431-9681","position":13,"is_corresponding":false},{"id":262129,"name":"Adam J. Fike","orcid":"0000-0002-7105-6162","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-19T01:09:25.015646Z","pmid":"37200190","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}