{"doi":"10.1016/j.celrep.2023.112503","title":"Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants","abstract":"Striking antibody evasion by emerging circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants drives the identification of broadly neutralizing antibodies (bNAbs). However, how a bNAb acquires increased neutralization breadth during antibody evolution is still elusive. Here, we identify a clonally related antibody family from a convalescent individual. One of the members, XG005, exhibits potent and broad neutralizing activities against SARS-CoV-2 variants, while the other members show significant reductions in neutralization breadth and potency, especially against the Omicron sublineages. Structural analysis visualizing the XG005-Omicron spike binding interface reveals how crucial somatic mutations endow XG005 with greater neutralization potency and breadth. A single administration of XG005 with extended half-life, reduced antibody-dependent enhancement (ADE) effect, and increased antibody product quality exhibits a high therapeutic efficacy in BA.2- and BA.5-challenged mice. Our results provide a natural example to show the importance of somatic hypermutation during antibody evolution for SARS-CoV-2 neutralization breadth and potency.","journal":"Cell Reports","year":2023,"id":362128,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1063529,"name":"Zhenguo Chen","orcid":"0000-0003-4748-9299","position":1,"is_corresponding":false},{"id":1115266,"name":"Yidan Gao","orcid":"0000-0001-9392-9377","position":2,"is_corresponding":false},{"id":1115769,"name":"Zegen Wang","orcid":null,"position":3,"is_corresponding":false},{"id":1115267,"name":"Jiarong Wang","orcid":"0009-0001-7249-5300","position":4,"is_corresponding":false},{"id":1115770,"name":"Bing‐Yu Chiang","orcid":null,"position":5,"is_corresponding":false},{"id":301423,"name":"Yunjiao Zhou","orcid":"0000-0002-0937-3570","position":6,"is_corresponding":false},{"id":1115771,"name":"Yuru Han","orcid":null,"position":7,"is_corresponding":false},{"id":1115772,"name":"Wuqiang Zhan","orcid":null,"position":8,"is_corresponding":false},{"id":1115268,"name":"Minxiang Xie","orcid":"0000-0003-0108-9556","position":9,"is_corresponding":false},{"id":621385,"name":"Weiyu Jiang","orcid":"0000-0001-6199-4289","position":10,"is_corresponding":false},{"id":1115269,"name":"Xiang Zhang","orcid":"0000-0002-4257-5617","position":11,"is_corresponding":false},{"id":1115773,"name":"Aihua Hao","orcid":null,"position":12,"is_corresponding":false},{"id":1115270,"name":"Anqi Xia","orcid":"0000-0001-9638-3074","position":13,"is_corresponding":false},{"id":1115271,"name":"Jiaying He","orcid":"0000-0002-0324-7135","position":14,"is_corresponding":false},{"id":1115272,"name":"Song Xue","orcid":"0009-0002-6691-924X","position":15,"is_corresponding":false},{"id":623046,"name":"Christian Mayer","orcid":"0000-0003-3152-5574","position":16,"is_corresponding":false},{"id":1115273,"name":"Fan Wu","orcid":"0000-0003-1039-3752","position":17,"is_corresponding":false},{"id":1115274,"name":"Bin Wang","orcid":"0000-0002-4869-1352","position":18,"is_corresponding":false},{"id":1115774,"name":"Lunan Zhang","orcid":null,"position":19,"is_corresponding":false},{"id":515153,"name":"Lei Sun","orcid":"0000-0001-7047-9529","position":20,"is_corresponding":false},{"id":301420,"name":"Qiao Wang","orcid":"0000-0001-6416-1733","position":21,"is_corresponding":false},{"id":1115265,"name":"Jianbo Wu","orcid":"0000-0002-3574-5585","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T01:14:19.266946Z","pmid":"37178120","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}