{"doi":"10.1016/j.celrep.2023.112501","title":"Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population","abstract":"Locoregional monotherapy with heterodimeric interleukin (IL)-15 (hetIL-15) in a triple-negative breast cancer (TNBC) orthotopic mouse model resulted in tumor eradication in 40% of treated mice, reduction of metastasis, and induction of immunological memory against breast cancer cells. hetIL-15 re-shaped the tumor microenvironment by promoting the intratumoral accumulation of cytotoxic lymphocytes, conventional type 1 dendritic cells (cDC1s), and a dendritic cell (DC) population expressing both CD103 and CD11b markers. These CD103 int CD11b + DCs share phenotypic and gene expression characteristics with both cDC1s and cDC2s, have transcriptomic profiles more similar to monocyte-derived DCs (moDCs), and correlate with tumor regression. Therefore, hetIL-15, a cytokine directly affecting lymphocytes and inducing cytotoxic cells, also has an indirect rapid and significant effect on the recruitment of myeloid cells, initiating a cascade for tumor elimination through innate and adoptive immune mechanisms. The intratumoral CD103 int CD11b + DC population induced by hetIL-15 may be targeted for the development of additional cancer immunotherapy approaches.","journal":"Cell Reports","year":2023,"id":365523,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":621573,"name":"Sevasti Karaliota","orcid":"0000-0001-7226-8207","position":1,"is_corresponding":false},{"id":663378,"name":"Vasiliki Stravokefalou","orcid":"0000-0002-1205-5805","position":2,"is_corresponding":false},{"id":388226,"name":"Matthew Angel","orcid":"0000-0002-3882-1504","position":3,"is_corresponding":false},{"id":1121377,"name":"Bethany A. Nagy","orcid":"0009-0004-8056-6641","position":4,"is_corresponding":false},{"id":240431,"name":"Katherine C. Goldfarbmuren","orcid":"0000-0001-8774-7454","position":5,"is_corresponding":false},{"id":258851,"name":"Cristina Bergamaschi","orcid":"0000-0003-1030-2662","position":6,"is_corresponding":false},{"id":258859,"name":"Barbara K. Felber","orcid":"0000-0001-8925-8128","position":7,"is_corresponding":false},{"id":258860,"name":"George N. Pavlakis","orcid":"0000-0002-4027-4036","position":8,"is_corresponding":false},{"id":258854,"name":"Dimitris Stellas","orcid":"0000-0002-7787-3921","position":0,"is_corresponding":true}],"reference_count":122,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:14:50.885797Z","pmid":"37178117","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}