{"doi":"10.1016/j.celrep.2023.112494","title":"Competition between skin antimicrobial peptides and commensal bacteria in type 2 inflammation enables survival of S. aureus","abstract":"During inflammation, the skin deploys antimicrobial peptides (AMPs) yet during allergic inflammation it becomes more susceptible to Staphylococcus aureus . To understand this contradiction, single-cell sequencing of Il4ra −/− mice combined with skin microbiome analysis reveals that lower production of AMPs from interleukin-4 receptor α (IL-4Rα) activation selectively inhibits survival of antibiotic-producing strains of coagulase-negative Staphylococcus (CoNS). Diminished AMPs under conditions of T helper type 2 (Th2) inflammation enable expansion of CoNS strains without antibiotic activity and increase Staphylococcus aureus ( S. aureus ), recapitulating the microbiome on humans with atopic dermatitis. This response is rescued in Camp −/− mice or after topical steroids, since further inhibition of AMPs enables survival of antibiotic-producing CoNS strains. In conditions of Th17 inflammation, a higher expression of host AMPs is sufficient to directly inhibit S. aureus survival . These results show that antimicrobials produced by the host and commensal bacteria each act to control S. aureus on the skin.","journal":"Cell Reports","year":2023,"id":321418,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9445,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1033491,"name":"S. Brinton","orcid":"0000-0003-1014-2566","position":1,"is_corresponding":false},{"id":385677,"name":"Kellen Cavagnero","orcid":"0000-0003-4160-6394","position":2,"is_corresponding":false},{"id":279042,"name":"Alan M. O’Neill","orcid":"0000-0002-5892-6477","position":3,"is_corresponding":false},{"id":1023975,"name":"Yang Chen","orcid":"0000-0002-0164-8971","position":4,"is_corresponding":false},{"id":356165,"name":"Tatsuya Dokoshi","orcid":"0000-0003-3678-6781","position":5,"is_corresponding":false},{"id":249748,"name":"Anna M. Butcher","orcid":"0009-0008-4807-2907","position":6,"is_corresponding":false},{"id":1033492,"name":"Olive Osuoji","orcid":"0000-0003-1918-3903","position":7,"is_corresponding":false},{"id":249752,"name":"Faiza Shafiq","orcid":"0000-0001-6211-7712","position":8,"is_corresponding":false},{"id":369655,"name":"Josh L. Espinoza","orcid":"0000-0003-3447-3845","position":9,"is_corresponding":false},{"id":28878,"name":"Christopher L. Dupont","orcid":"0000-0002-0896-6542","position":10,"is_corresponding":false},{"id":249753,"name":"Tissa Hata","orcid":"0000-0003-0183-4210","position":11,"is_corresponding":false},{"id":249754,"name":"Richard L. Gallo","orcid":"0000-0002-1401-7861","position":12,"is_corresponding":false},{"id":249749,"name":"Teruaki Nakatsuji","orcid":"0000-0002-6187-2991","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T01:07:32.611759Z","pmid":"37167061","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}