{"doi":"10.1016/j.celrep.2023.112388","title":"Lysine long-chain fatty acylation regulates the TEAD transcription factor","abstract":null,"journal":"Cell Reports","year":2023,"id":644341,"datarank":0.5354055982752418,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.16266960080704168,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.16266960080704168,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":10,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":577238,"name":"Takehiro Suzuki","orcid":"0000-0002-0585-6305","position":1,"is_corresponding":false},{"id":287608,"name":"Kosuke Dodo","orcid":"0000-0001-6008-2915","position":2,"is_corresponding":false},{"id":1291657,"name":"Kenji Ohgane","orcid":"0000-0003-0565-6503","position":3,"is_corresponding":false},{"id":1677060,"name":"Yasue Ichikawa","orcid":null,"position":4,"is_corresponding":false},{"id":1677061,"name":"Kota Koike","orcid":null,"position":5,"is_corresponding":false},{"id":1175052,"name":"Satoshi Morita","orcid":"0000-0002-1834-4755","position":6,"is_corresponding":false},{"id":111582,"name":"Takashi Umehara","orcid":"0000-0003-3464-2960","position":7,"is_corresponding":false},{"id":1457111,"name":"Kenji Ogawa","orcid":null,"position":8,"is_corresponding":false},{"id":287607,"name":"Mikiko Sodeoka","orcid":"0000-0002-1344-364X","position":9,"is_corresponding":false},{"id":577240,"name":"Naoshi Dohmae","orcid":"0000-0002-5242-9410","position":10,"is_corresponding":false},{"id":114450,"name":"Minoru Yoshida","orcid":null,"position":11,"is_corresponding":false},{"id":1044473,"name":"Akihiro Ito","orcid":"0000-0003-0908-8929","position":12,"is_corresponding":false},{"id":1677059,"name":"Kota Noritsugu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Lysine long-chain fatty acylation regulates the TEAD transcription factor","abstract":"TEAD transcription factors are responsible for the transcriptional output of Hippo signaling. TEAD activity is primarily regulated by phosphorylation of its coactivators, YAP and TAZ. In addition, cysteine palmitoylation has recently been shown to regulate TEAD activity. Here, we report lysine long-chain fatty acylation as a posttranslational modification of TEADs. Lysine fatty acylation occurs spontaneously via intramolecular transfer of acyl groups from the proximal acylated cysteine residue. Lysine fatty acylation, like cysteine palmitoylation, contributes to the transcriptional activity of TEADs by enhancing the interaction with YAP and TAZ, but it is more stable than cysteine acylation, suggesting that the lysine fatty-acylated TEAD acts as a \"stable active form.\" Significantly, lysine fatty acylation of TEAD increased upon Hippo signaling activation despite a decrease in cysteine acylation. Our results provide insight into the role of fatty-acyl modifications in the regulation of TEAD activity.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37060904","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Japan Society for the Promotion of Science","grant_id":"18H05293","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"19H02890","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"19H05640","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"19K22271","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"20K15720","title":null},{"funder_name":"Japan Society for the Promotion of Science","grant_id":"20K20591","title":null},{"funder_name":"RIKEN","grant_id":"JP21fk0310112","title":null}],"total_grants":7,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://www.cell.com/article/S2211124723003996/pdf","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124723003996?httpAccept=text/xml","host_type":"publisher"},{"url":"https://api.elsevier.com/content/article/PII:S2211124723003996?httpAccept=text/plain","host_type":"publisher"}],"fields_of_study":["Transcription Factors","TEA Domain Transcription Factors","Lysine","Cysteine","Signal Transduction","Acylation"],"mesh_terms":["Transcription Factors","TEA Domain Transcription Factors","Lysine","Cysteine","Signal Transduction","Acylation"],"keywords":["CP: Cell biology","Hippo pathway","TEAD","cysteine palmitoylation","lysine long-chain fatty acylation","transcription factor"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T00:56:57.651920Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}