{"doi":"10.1016/j.celrep.2023.112326","title":"Fc-mediated pan-sarbecovirus protection after alphavirus vector vaccination","abstract":"Group 2B β-coronaviruses (sarbecoviruses) have caused regional and global epidemics in modern history. Here, we evaluate the mechanisms of cross-sarbecovirus protective immunity, currently less clear yet important for pan-sarbecovirus vaccine development, using a panel of alphavirus-vectored vaccines covering bat to human strains. While vaccination does not prevent virus replication, it protects against lethal heterologous disease outcomes in both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and clade 2 bat sarbecovirus challenge models. The spike vaccines tested primarily elicit a highly S1-specific homologous neutralizing antibody response with no detectable cross-virus neutralization. Rather, non-neutralizing antibody functions, mechanistically linked to FcgR4 and spike S2, mediate cross-protection in wild-type mice. Protection is lost in FcR knockout mice, further supporting a model for non-neutralizing, protective antibodies. These data highlight the importance of FcR-mediated cross-protective immune responses in universal pan-sarbecovirus vaccine designs.","journal":"Cell Reports","year":2023,"id":320037,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9601,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":105111,"name":"Sarah R. Leist","orcid":"0000-0002-4989-5381","position":1,"is_corresponding":false},{"id":105500,"name":"Kenneth H. Dinnon","orcid":"0000-0002-8942-1551","position":2,"is_corresponding":false},{"id":105602,"name":"Ande West","orcid":"0000-0001-7381-9533","position":3,"is_corresponding":false},{"id":105603,"name":"Kendra L. Gully","orcid":"0000-0001-5742-2341","position":4,"is_corresponding":false},{"id":646163,"name":"Elizabeth J. Anderson","orcid":"0000-0001-7877-1639","position":5,"is_corresponding":false},{"id":324959,"name":"Jennifer F. Loome","orcid":null,"position":6,"is_corresponding":false},{"id":333821,"name":"Emily A. Madden","orcid":"0000-0003-0209-914X","position":7,"is_corresponding":false},{"id":590392,"name":"John M. Powers","orcid":"0000-0001-9926-4548","position":8,"is_corresponding":false},{"id":105112,"name":"Alexandra Schäfer","orcid":null,"position":9,"is_corresponding":false},{"id":333826,"name":"Sanjay Sarkar","orcid":"0000-0003-0933-1415","position":10,"is_corresponding":false},{"id":1029917,"name":"Izabella N. Castillo","orcid":"0009-0003-2815-2807","position":11,"is_corresponding":false},{"id":912150,"name":"Jenny S. Maron","orcid":"0000-0001-5945-4945","position":12,"is_corresponding":false},{"id":302984,"name":"Ryan P. McNamara","orcid":"0000-0002-8866-3532","position":13,"is_corresponding":false},{"id":932049,"name":"Harry L. Bertera","orcid":"0000-0001-7431-6436","position":14,"is_corresponding":false},{"id":894117,"name":"Mark R. Zweigart","orcid":"0000-0001-5765-3203","position":15,"is_corresponding":false},{"id":1029918,"name":"Jaclyn S. Higgins","orcid":"0000-0003-1217-0907","position":16,"is_corresponding":false},{"id":353041,"name":"Brea K. Hampton","orcid":"0000-0001-7167-5652","position":17,"is_corresponding":false},{"id":103773,"name":"Lakshmanane Premkumar","orcid":"0000-0002-1736-1350","position":18,"is_corresponding":false},{"id":805827,"name":"Galit Alter","orcid":"0000-0002-9221-6735","position":19,"is_corresponding":false},{"id":105115,"name":"Stephanie A. Montgomery","orcid":"0000-0001-8012-5302","position":20,"is_corresponding":false},{"id":134869,"name":"Victoria K. Baxter","orcid":"0000-0003-0916-360X","position":21,"is_corresponding":false},{"id":275061,"name":"Mark T. Heise","orcid":"0000-0001-5829-8477","position":22,"is_corresponding":false},{"id":5952,"name":"Ralph S. Baric","orcid":"0000-0001-6827-8701","position":23,"is_corresponding":false},{"id":109139,"name":"Lily E. Adams","orcid":"0000-0001-7780-9973","position":0,"is_corresponding":true}],"reference_count":110,"raw_metadata":null,"created_at":"2026-07-19T01:07:17.361058Z","pmid":"37000623","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}