{"doi":"10.1016/j.celrep.2023.112283","title":"MrgprA3-expressing pruriceptors drive pruritogen-induced alloknesis through mechanosensitive Piezo2 channel","abstract":"Although touch and itch are coded by distinct neuronal populations, light touch also provokes itch in the presence of exogenous pruritogens, resulting in a phenomenon called alloknesis. However, the cellular and molecular mechanisms underlying the initiation of pruritogen-induced mechanical itch sensitization are poorly understood. Here, we show that intradermal injections of histamine or chloroquine (CQ) provoke alloknesis through activation of TRPV1- and MrgprA3-expressing prurioceptors, and functional ablation of these neurons reverses pruritogen-induced alloknesis. Moreover, genetic ablation of mechanosensitive Piezo2 channel function from MrgprA3-expressing prurioceptors also dampens pruritogen-induced alloknesis. Mechanistically, histamine and CQ sensitize Piezo2 channel function, at least in part, through activation of the phospholipase C (PLC) and protein kinase C-δ (PKCδ) signaling. Collectively, our data find a TRPV1 + /MrgprA3 + prurioceptor-Piezo2 signaling axis in the initiation of pruritogen-induced mechanical itch sensitization in the skin.","journal":"Cell Reports","year":2023,"id":327598,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9558,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":634226,"name":"Yonghui Zhao","orcid":"0000-0002-6192-4130","position":1,"is_corresponding":false},{"id":498170,"name":"Zili Xie","orcid":"0000-0002-9060-6780","position":2,"is_corresponding":false},{"id":307873,"name":"Huan‐Xiang Zhou","orcid":"0000-0001-9020-0302","position":3,"is_corresponding":false},{"id":297467,"name":"Xinzhong Dong","orcid":"0000-0002-9750-7718","position":4,"is_corresponding":false},{"id":278785,"name":"Gregory F. Wu","orcid":"0000-0003-3588-0637","position":5,"is_corresponding":false},{"id":230329,"name":"Brian Kim","orcid":"0000-0002-8100-7161","position":6,"is_corresponding":false},{"id":445603,"name":"Jing Feng","orcid":"0000-0001-6726-7912","position":7,"is_corresponding":false},{"id":249785,"name":"Hongzhen Hu","orcid":"0000-0002-8967-7522","position":8,"is_corresponding":false},{"id":989162,"name":"Ping Lü","orcid":"0000-0002-3787-4495","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T01:08:47.581262Z","pmid":"36961815","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}