{"doi":"10.1016/j.celrep.2023.112274","title":"Latexin regulates sex dimorphism in hematopoiesis via gender-specific differential expression of microRNA 98-3p and thrombospondin 1","abstract":"Hematopoietic stem cells (HSCs) have the ability to self-renew and differentiate to all blood cell types. HSCs and their differentiated progeny show sex/gender differences. The fundamental mechanisms remain largely unexplored. We previously reported that latexin ( Lxn ) deletion increased HSC survival and repopulation capacity in female mice. Here, we find no differences in HSC function and hematopoiesis in Lxn knockout ( Lxn −/− ) male mice under physiologic and myelosuppressive conditions. We further find that Thbs1 , a downstream target gene of Lxn in female HSCs, is repressed in male HSCs. Male-specific high expression of microRNA 98-3p (miR98-3p) contributes to Thbs1 suppression in male HSCs, thus abrogating the functional effect of Lxn in male HSCs and hematopoiesis. These findings uncover a regulatory mechanism involving a sex-chromosome-related microRNA and its differential control of Lxn-Thbs1 signaling in hematopoiesis and shed light on the process underlying sex dimorphism in both normal and malignant hematopoiesis.","journal":"Cell Reports","year":2023,"id":370869,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9505,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1130191,"name":"Cuiping Zhang","orcid":"0000-0002-0688-560X","position":1,"is_corresponding":false},{"id":1130192,"name":"Fang Wang","orcid":"0000-0001-7676-091X","position":2,"is_corresponding":false},{"id":1130590,"name":"Xinghui Zhao","orcid":null,"position":3,"is_corresponding":false},{"id":327979,"name":"Shuxia Wang","orcid":"0000-0003-3102-2117","position":4,"is_corresponding":false},{"id":867230,"name":"Jinpeng Liu","orcid":"0009-0008-4305-8305","position":5,"is_corresponding":false},{"id":271896,"name":"Daheng He","orcid":"0000-0003-0399-2466","position":6,"is_corresponding":false},{"id":731306,"name":"Chi Chiu Wang","orcid":"0000-0002-3928-7278","position":7,"is_corresponding":false},{"id":517991,"name":"Feng‐Chun Yang","orcid":"0000-0001-8524-4095","position":8,"is_corresponding":false},{"id":1049856,"name":"Sheng Tong","orcid":"0000-0001-8632-7933","position":9,"is_corresponding":false},{"id":1111659,"name":"Ying Liang","orcid":"0000-0003-4533-5472","position":10,"is_corresponding":false},{"id":1130190,"name":"Xiaojing Cui","orcid":"0009-0003-1152-8951","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-19T01:15:41.237096Z","pmid":"36933218","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}