{"doi":"10.1016/j.celrep.2023.112255","title":"Neonatal SHIV infection in rhesus macaques elicited heterologous HIV-1-neutralizing antibodies","abstract":"Infants and children infected with human immunodeficiency virus (HIV)-1 have been shown to develop neutralizing antibodies (nAbs) against heterologous HIV-1 strains, characteristic of broadly nAbs (bnAbs). Thus, having a neonatal model for the induction of heterologous HIV-1 nAbs may provide insights into the mechanisms of neonatal bnAb development. Here, we describe a neonatal model for heterologous HIV-1 nAb induction in pathogenic simian-HIV (SHIV)-infected rhesus macaques (RMs). Viral envelope (env) evolution showed mutations at multiple sites, including nAb epitopes. All 13 RMs generated plasma autologous HIV-1 nAbs. However, 8/13 (62%) RMs generated heterologous HIV-1 nAbs with increasing potency over time, albeit with limited breadth, and mapped to multiple nAb epitopes, suggestive of a polyclonal response. Moreover, plasma heterologous HIV-1 nAb development was associated with antigen-specific, lymph-node-derived germinal center activity. We define a neonatal model for heterologous HIV-1 nAb induction that may inform future pediatric HIV-1 vaccines for bnAb induction in infants and children.","journal":"Cell Reports","year":2023,"id":370858,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":523778,"name":"Hui Li","orcid":"0000-0003-2600-4838","position":1,"is_corresponding":false},{"id":332540,"name":"Xiaoying Shen","orcid":"0000-0002-8387-3952","position":2,"is_corresponding":false},{"id":842177,"name":"Mitchell Martin","orcid":"0000-0002-1043-4465","position":3,"is_corresponding":false},{"id":746112,"name":"Yue Chen","orcid":"0000-0001-7325-1845","position":4,"is_corresponding":false},{"id":498299,"name":"Madison Berry","orcid":null,"position":5,"is_corresponding":false},{"id":640198,"name":"Tyler Evangelous","orcid":"0000-0001-9858-2114","position":6,"is_corresponding":false},{"id":225650,"name":"Andrew N. 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Denny","orcid":"0000-0002-7364-8276","position":17,"is_corresponding":false},{"id":32982,"name":"M. Anthony Moody","orcid":null,"position":18,"is_corresponding":false},{"id":665687,"name":"John Misamore","orcid":null,"position":19,"is_corresponding":false},{"id":4374,"name":"Mark G. Lewis","orcid":"0000-0001-7852-0135","position":20,"is_corresponding":false},{"id":274230,"name":"Kevin Wiehe","orcid":"0000-0001-9933-9618","position":21,"is_corresponding":false},{"id":267571,"name":"Derek W. Cain","orcid":"0000-0002-5988-6729","position":22,"is_corresponding":false},{"id":103755,"name":"David C. Montefiori","orcid":"0000-0003-0856-6319","position":23,"is_corresponding":false},{"id":253820,"name":"George M. Shaw","orcid":"0000-0002-2338-4532","position":24,"is_corresponding":false},{"id":280544,"name":"Wilton B. 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